Erythropoiesis stimulation in acute ischemic syndromes

Heart Failure Clinics
Willem-Peter T RuifrokDirk J van Veldhuisen

Abstract

Erythropoietin (EPO) is a hematopoietic hormone with extensive nonhematopoietic properties. The discovery of an EPO receptor outside the hematopoietic system has fuelled research into the beneficial effects of EPO for various conditions, predominantly in cardiovascular disease. Experimental evidence has revealed the cytoprotective properties of EPO, and it seems that the EPO-EPO receptor system provides a powerful backbone against acute myocardial ischemia, gaining from the different properties of EPO. There is an ongoing discussion about possible discrepancy between preclinical and clinical effects of EPO on the cardiovascular system. Large, randomized, placebo-controlled clinical trials are underway to give a final verdict on EPO treatment for acute coronary syndromes.

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Citations

Oct 19, 2017·Work : a Journal of Prevention, Assessment, and Rehabilitation·Eveline HeitinkJosephine Engels

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