Erythropoietic response to oral iron in patients with nondialysis-dependent chronic kidney disease in the FIND-CKD trial


Clinical Nephrology
Iain C MacdougallSimon D Roger

Abstract

To evaluate erythropoietic response rates to oral iron over time in iron-deficient anemic patients with nondialysis-dependent chronic kidney disease (ND-CKD). FIND-CKD was a 1-year, randomized, multicenter trial of iron therapy in patients with ND-CKD, anemia, and iron deficiency, without erythropoiesis-stimulating agent (ESA) therapy. Patients with active infection or C-reactive protein > 20 mg/L were excluded. In this post-hoc analysis, response was defined as ≥ 1 g/dL increase in hemoglobin (Hb) from baseline, before initiation of alternative anemia therapy (i.e., ESA, transfusion, or intravenous iron). 308 patients received oral iron (200 mg elemental iron/day). Mean (SD) Hb at baseline was 10.4 (0.7) g/dL. At week 4, Hb data were available from 292 patients without alternative anemia therapy: 63/292 (21.6%) showed a response. Among the 229 nonresponders at week 4, 48.8% showed a cumulative response on ≥ 1 occasion by week 52 (11.1%, 19.9%, 25.9%, and 28.7% had a response at weeks 8, 12, 24, and 52, respectively), and 27.9% had received alternative iron therapy by week 52. Baseline levels of Hb, ferritin, and transferrin saturation were lower in responders than in nonresponders. Neither concomitant medication nor adherence ...Continue Reading

Citations

Jun 16, 2018·Current Opinion in Nephrology and Hypertension·Iain C Macdougall
Aug 29, 2018·Pharmaceuticals·Sunil BhandariHal Drakesmith
Oct 6, 2018·Pharmaceuticals·Susana Gómez-RamírezManuel Muñoz
Feb 23, 2019·The Cochrane Database of Systematic Reviews·Emma L O'LoneJonathan C Craig
Mar 14, 2018·Drugs·Lesley J Scott
Oct 8, 2020·International Urology and Nephrology·Glogowski TomaszMalyszko Jolanta
Feb 1, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Aleix CasesUNKNOWN en representación del Grupo de Anemia de la S.E.N.
Mar 7, 2021·Journal of Clinical Medicine·Lucia Del Vecchio, Roberto Minutolo
Jun 1, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Aleix CasesUNKNOWN en representación del Grupode Anemia de la S.E.N.

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NCT00994318

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