Erythropoietin: A potential drug in the management of diabetic neuropathy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Samuel Suarez-MendezDeysi Y Bermúdez-Ocaña

Abstract

Erythropoietin (EPO) is required for promoting the progress of erythroid differentiation. However, the discovery of EPO and the EPO receptor (EPOR) in the nervous system may contribute to new treatment strategies for the use of EPO in neurodegenerative disorders. Diabetic neuropathy is a neurodegenerative disease that affects a large proportion of diabetic patients and results in alterations in functionality, mood and sleep. The pathogenic mechanisms generating diabetic neuropathy involve: Schwannopathy, polyol pathway activity, advanced glycation end-products (AGEs) accumulation, protein kinase C (PKC) activity, increased hexosamine pathway flux, oxidative stress, nitric oxide and inflammation. In this sense, evidence from both clinical and experimental studies indicates that EPO may reverse diabetic neuropathy through an antioxidant action by decreasing pro-inflammatory cytokines, restoring Na+/K+-ATPase activity, and blocking the generation of pro-apoptotic proteins. The aim of this review is to discuss the neuroprotector effect of EPO on pathogenic mechanisms of diabetic neuropathy.

References

May 14, 1999·Trends in Endocrinology and Metabolism : TEM·S N ConstantinescuH F Lodish
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Harshini MukundanNancy L Kanagy
Jan 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roberto BianchiPietro Ghezzi
Aug 10, 2004·The Journal of Experimental Biology·Hugo H Marti
Oct 20, 2004·Trends in Pharmacological Sciences·Kenneth MaieseZhao Zhong Chong
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Kenneth MaieseZhao Zhong Chong
Apr 28, 2007·Diabetes Research and Clinical Practice·Soroku YagihashiRyuichi Wada
Oct 16, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ronald J McPherson, Sandra E Juul
Feb 27, 2008·Cytokine & Growth Factor Reviews·Kenneth MaieseYan Chen Shang
Mar 26, 2008·Brain : a Journal of Neurology·Arun V KrishnanMatthew C Kiernan
Jun 10, 2008·Investigative Ophthalmology & Visual Science·Lin XieShibo Tang
Jul 12, 2008·Pharmacology & Therapeutics·James L EdwardsEva L Feldman
Dec 2, 2008·Expert Reviews in Molecular Medicine·Constance Tom NoguchiYi Jia
Jul 25, 2009·Investigative Ophthalmology & Visual Science·Jianfeng ShenGuo-Tong Xu
Oct 6, 2009·TheScientificWorldJournal·Kenneth MaieseYan Chen Shang
Nov 20, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Giuseppe LauriaRenato Mantegazza
Dec 26, 2009·Cell Calcium·Paul Fernyhough, Nigel A Calcutt
Dec 15, 2010·The Journal of Experimental Medicine·Diana ChoiMinna Woo
Jan 18, 2011·Progress in Molecular Biology and Translational Science·Carol M TroyYing Y Jean
Apr 5, 2011·Trends in Neurosciences·Humberto Gutierrez, Alun M Davies
Apr 8, 2011·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A ZengiG Ozgen
Jul 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andreu ViaderJeffrey Milbrandt
Aug 25, 2011·Current Medicinal Chemistry·Z ZhangH Shi
Oct 26, 2011·Current Neurovascular Research·Yan Chen ShangKenneth Maiese
May 23, 2012·Lancet Neurology·Brian C CallaghanEva L Feldman
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer ZenkerRoman Chrast
Jul 18, 2012·Nature·Youngjin LeeJeffrey D Rothstein
Jul 24, 2012·Seminars in Vascular Surgery·Andrew J M Boulton
Oct 31, 2012·International Journal of Molecular Sciences·Kenneth MaieseShaohui Wang
Dec 26, 2012·Trends in Molecular Medicine·Kenneth MaieseShaohui Wang
Mar 5, 2013·Cold Spring Harbor Perspectives in Medicine·H Franklin Bunn
Jun 1, 2013·Cell Biochemistry and Biophysics·Louis S Premkumar, Reddy M Pabbidi
Jun 6, 2013·Oxidative Medicine and Cellular Longevity·Asieh Hosseini, Mohammad Abdollahi
Sep 24, 2013·Molecular and Cellular Biochemistry·Guo-Bin WangWei-Fang Zhang
Dec 3, 2013·Journal of the Neurological Sciences·Wooyoung JangHee-Tae Kim
Jan 24, 2011·Journal of Diabetes Investigation·Soroku YagihashiKazuhiro Sugimoto
Aug 22, 2014·Therapeutics and Clinical Risk Management·Alberto PalazzuoliRanuccio Nuti

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