Erythropoietin ameliorates damage to the placenta and fetal liver induced by exposure to lipopolysaccharide

Placenta
F DijkstraS Rees

Abstract

Intrauterine infection and inflammation have been causally linked to preterm birth and fetal brain injury. Using an ovine model of endotoxin-induced brain injury we have recently shown that recombinant human erythropoietin (rhEPO) reduces brain injury and protects against damage to myelination in major myelinated axon tracts. Our present objective was to determine whether rhEPO is also protective of the placenta and the fetal liver, organs which could influence fetal well-being. At 107 +/- 1 days of gestational age (DGA) chronically catheterized fetal sheep were randomly assigned to receive, on 3 consecutive days, either: 1) an i.v. bolus dose of lipopolysaccharide (LPS; approximately 0.9 microg/kg; n = 8); 2) i.v. bolus dose of LPS, followed at 1 h by 5000 IU/kg of rhEPO (LPS + rhEPO, n = 8); 3) rhEPO (n = 3). Seven untreated fetuses served as controls (n = 7). The placenta and fetal liver were examined histologically at 116 +/- 1 DGA; a placental injury index was formulated comprising measures of placental area, apoptosis, tissue injury and the size of the intervillous space. In LPS-exposed fetuses this index was greater than in control or rhEPO alone fetuses (p < 0.02). Treatment of LPS-exposed fetuses with rhEPO resulted in...Continue Reading

References

May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M D JosephsL L Moldawer
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A L SirénP Ghezzi
Jun 8, 2001·Journal of the Society for Gynecologic Investigation·Y GarnierT H Hasaart
Mar 29, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Olaf DammannAlan Leviton
Apr 3, 2002·Pediatrics·Kaori KumazakiMasanori Fujimura
Jun 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alfredo GorioMichael Brines
Nov 20, 2002·Pediatric Research·Jhodie R DuncanSandra M Rees
Apr 17, 2003·The Journal of Obstetrics and Gynaecology Research·Kazuo AsagiriTakafumi Kudo
Nov 19, 2003·The European Journal of Neuroscience·Ofelia María Martínez-EstradaMyriam Fabre
Jan 8, 2004·American Journal of Obstetrics and Gynecology·Lowell E DavisRobert A Brace
Dec 8, 2004·Journal of the Society for Gynecologic Investigation·Cecilia Y CheungRobert A Brace
Jan 31, 2006·Journal of the Society for Gynecologic Investigation·Jhodie R DuncanSandra M Rees
Dec 8, 2006·Archives of Pathology & Laboratory Medicine·Roberto N MirandaEmad Kaabipour
Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aylin TarcanBerkan Gürakan
Sep 26, 2007·Nature Reviews. Immunology·Jordan S Pober, William C Sessa
Oct 19, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yves GarnierBerthold Huppertz
Nov 6, 2007·Seminars in Liver Disease·Laurie D DeLeve
Dec 25, 2007·The Journal of Pediatrics·Alistair J GunnUNKNOWN CoolCap Study Group
Aug 5, 2008·Pediatrics·Jean-Claude FauchèreHans Ulrich Bucher
May 22, 2009·Journal of Neuropathology and Experimental Neurology·Sandra M ReesTerrie Inder
Feb 10, 2010·Journal of Neuropathology and Experimental Neurology·Sandra ReesRichard Harding

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Citations

Aug 8, 2013·Obstetrical & Gynecological Survey·Laura SienasJames Smith
Oct 1, 2011·Journal of Perinatal Medicine·Roberto RomeroMoshe Mazor
Apr 30, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sandra ReesDavid Walker
Feb 12, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ryan F Brown, Yadranko Ducic
Jun 9, 2020·American Journal of Reproductive Immunology : AJRI·Jie ZhangYanqun Chang

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