Abstract
Inflammatory modulation mediated by microglial M1/M2 polarization is one of the main pathophysiological processes involved in early brain injury (EBI) after subarachnoid haemorrhage (SAH). Previous studies have shown that recombinant human erythropoietin (rhEPO) alleviates EBI following experimental SAH. However, the mechanisms of this beneficial effect are still poorly understood. Recent research has suggested that EPO shows anti-inflammatory properties. Therefore, we tried to analyse whether rhEPO administration influenced microglial M1/M2 polarization in early brain injury after SAH and to identify the underlying molecular mechanism of any such effect. We found that treatment with rhEPO markedly ameliorated SAH-induced EBI, as shown by reductions in brain cell apoptosis, neuronal necrosis, albumin exudation and brain edema. Moreover, the expression levels of p-JAK2 and p-STAT3 were significantly increased in the cortex after SAH induction and were further increased by EPO treatment; in addition, the p-JAK2 inhibitor AZD1480 impaired the protective effect of EPO against SAH-induced EBI in vivo. Furthermore, EPO promoted the polarization of microglia towards the protective M2 phenotype and alleviated inflammation. In cultured ...Continue Reading
Citations
Feb 8, 2018·Brain Sciences·Hirofumi Nishikawa, Hidenori Suzuki
Nov 5, 2019·NeoReviews·Jessie R Maxwell, Robin K Ohls
Nov 5, 2019·NeoReviews·Olga RomantsikDavid Ley
Jan 8, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·A P Coulibaly, J J Provencio
Jan 9, 2020·The Journal of Physiology·Guido WassinkAlistair J Gunn
Feb 20, 2020·Current Pharmaceutical Design·Jerónimo AuzmendiAmalia Merelli
Oct 16, 2018·Frontiers in Cellular Neuroscience·Shenandoah RobinsonLauren L Jantzie
Dec 7, 2019·Cellular and Molecular Neurobiology·Kevin Min Wei KheySherif Hanafy Mahmoud
Sep 23, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Deeya GaindhWei Lu
Feb 20, 2019·Frontiers in Cellular Neuroscience·Jun WuLan-Jun Li
Jan 21, 2020·Bioscience Reports·Shuang QiShanshan Yu
Aug 25, 2020·BioMed Research International·Rui LiFeng Miao
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Carmen Hierro-BujalanceMonica Garcia-Alloza
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia
Dec 15, 2020·Experimental Neurology·Rongliang WangYumin Luo
Mar 8, 2020·International Immunopharmacology·Shanshan YuLongyun Li
Mar 1, 2021·Genes, Brain, and Behavior·Zhi Yuan ZhengGeorge Kwok Chu Wong
Oct 7, 2020·Neurochemistry International·Haiyu ZhangGuangyou Wang
Apr 4, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhongnan YangFengmin Shao
Dec 1, 2020·Aging·Peng LiBin Yi
Jun 8, 2021·Neural Plasticity·Xin HuangLiang Wen
Jul 3, 2021·International Journal of Molecular Sciences·Teodora Larisa TimisIoan Stefan Florian
Jul 21, 2021·Brain Research Bulletin·Zunwei LiuQihang Guo
Aug 20, 2021·Brain Communications·Guido WassinkAlistair J Gunn
Oct 15, 2021·Stroke and Vascular Neurology·Zhiyuan Vera ZhengGeorge K C Wong