Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria.

Malaria Journal
Isabelle M MedanaGareth D Turner

Abstract

Facilitation of endogenous neuroprotective pathways, such as the erythropoietin (Epo) pathway, has been proposed as adjuvant treatment strategies in cerebral malaria. Whether different endogenous protein expression levels of Epo or differences in the abundance of its receptor components could account for the extent of structural neuropathological changes or neurological complications in adults with severe malaria was investigated. High sensitivity immunohistochemistry was used to assess the frequency, distribution and concordance of Epo and components of its homodimeric and heteromeric receptors, Epo receptor and CD131, within the brainstem of adults who died of severe malaria. The following relationships with Epo and its receptor components were also defined: (i) sequestration and indicators of hypoxia; (ii) vascular damage in the form of plasma protein leakage and haemorrhage; (iii) clinical complications and neuropathological features of severe malaria disease. Brainstems of patients dying in the UK from unrelated non-infectious causes were examined for comparison. The incidence of endogenous Epo in parenchymal brain cells did not greatly differ between severe malaria and non-neurological UK controls at the time of death. Ho...Continue Reading

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Citations

Sep 18, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Estela ShabaniChandy C John
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Sep 13, 2011·Expert Review of Anti-infective Therapy·Sarah J HigginsW Conrad Liles

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