Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Elena T ZakharovaVadim B Vasilyev

Abstract

Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory, antitumour, antiphlogistic effects. Previously we demonstrated its capacity to stabilize in vivo HIF-1-alpha and HIF-2-alpha, which are redox-sensitive multiaimed transcription factors. Various tissues of animals receiving recombinant human LF (rhLF) responded by expressing the HIF-1-alpha target genes, hence such proteins as erythropoietin (EPO), ceruloplasmin, etc. were synthesized in noticeable amounts. Among organs in which EPO synthesis occurred were brain, heart, spleen, liver, kidneys and lungs. Other researchers showed that EPO can act as a protectant against severe brain injury and status epilepticus in rats. Therefore, we tried rhLF as a protector against the severe neurologic disorders developed in rats, such as the rotenone-induced model of Parkinson's disease and experimental autoimmune encephalomyelitis as a model of multiple sclerosis, and observed its capacity to mitigate the grave symptoms. Moreover, an intraperitoneal injection of rhLF into mice 1 h after occlusion of the medial cerebral artery significantly diminished the necrosis area measured on the third day in the ischaemic brain. During this period EPO was synthesize...Continue Reading

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Citations

May 20, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hans J VogelPiera Valenti
Apr 17, 2021·Ageing Research Reviews·Johannes BurtscherGrégoire P Millet
May 1, 2021·Antioxidants·Stefano LorenzettiInga C Teller
Aug 8, 2021·Cells·Yu-Qi Li, Chuang Guo

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