Erythropoietin concentrations during 10 days of normobaric hypoxia under controlled environmental circumstances

Acta Physiologica Scandinavica
B BerglundL Wide

Abstract

Serum erythropoietin levels (s-[epo]), haemoglobin concentration ([Hb]), haematocrit (hct), and ferritin concentration ([fer]) were measured in seven healthy male volunteers (20-23 years) exposed continuously to hypoxia (PO(2) 14 kPa) for 10 days. Serum erythropoietin concentration increased significantly from 9.5 +/- 3.51 to 33.6 +/- 11.64 U L(-1) (P < 0.05) after 2 days of hypoxia. Thereafter, s-[epo] decreased. However, after 10 days s-[epo] was 18.7 +/- 5.83 U L(-1) which was still increased above the pre-hypoxia level (P < 0.05). Serum haemoglobin concentration and hct increased over the 10 days of hypoxia, [Hb] from 152 +/- 8.9 to 168 +/- 9.2 gL(-1) (P < 0.001), and hct from 43 +/- 2.4 to 49 +/- 2.6% (P < 0.001). Ferritin concentration decreased significantly during the hypoxic exposure from 82 +/- 46.9 to 44 +/- 31.7 mmol L(-1) after 10 days (P < 0.01). In conclusion, the initial increase of s-[epo] under controlled normobaric hypoxia was marked, 353%, and levelled off after 5-10 days at 62-97% above normoxia level. There was also a significant increase in [Hb] and hct and a decrease in [fer] after 10 days of exposure to normobaric hypoxia.

References

Sep 1, 1992·Journal of Applied Physiology·W KnauppH Steinberg
Nov 1, 1992·Sports Medicine·B Berglund
Jan 1, 1989·Annual Review of Physiology·C Bauer, A Kurtz
Apr 1, 1989·Journal of Applied Physiology·R M WinslowR Santolaya
Apr 1, 1989·Journal of Applied Physiology·K U EckardtC Bauer
May 1, 1989·British Journal of Haematology·L WideG Birgegård
Jan 1, 1988·Annual Review of Pharmacology and Toxicology·J W Fisher
Aug 1, 1985·Journal of Applied Physiology·J S Milledge, P M Cotes
May 30, 1974·The New England Journal of Medicine·D A LipschitzC A Finch
Jan 1, 1972·Journal of Applied Physiology·P H Abbrecht, J K Littell
Oct 1, 1984·Hospital Practice·L E Young
Sep 1, 1993·Journal of Applied Physiology·J T ReevesJ V Weil
Mar 1, 1997·Respiration Physiology·J A LoeppkyR C Roach
Jul 11, 1998·Scandinavian Journal of Medicine & Science in Sports·K Piehl AulinB Saltin

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Citations

Jun 17, 2010·Amino Acids·Lee TaylorLars R McNaughton
Feb 25, 2005·British Journal of Sports Medicine·B FriedmannP Bärtsch
Mar 19, 2013·Medicine and Science in Sports and Exercise·Peter RasmussenCarsten Lundby
Feb 18, 2014·European Journal of Applied Physiology·Anne-Kristine Meinild LundbyCarsten Lundby
May 12, 2005·Scandinavian Journal of Medicine & Science in Sports·C LundbyR Damsgaard
Jan 25, 2006·Scandinavian Journal of Medicine & Science in Sports·C Lundby, R Damsgaard
May 9, 2006·Medicine and Science in Sports and Exercise·Antonio J GonzálezNicolás Terrados
Jun 3, 2017·Journal of Applied Physiology·Christoph SiebenmannCarsten Lundby
Oct 29, 2011·Journal of Applied Physiology·Christoph SiebenmannCarsten Lundby
Sep 22, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Laura OberholzerCarsten Lundby
May 5, 2021·High Altitude Medicine & Biology·Thomas G DeLoughery

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