Erythropoietin-dependent autocrine secretion of tumor necrosis factor-alpha in hematopoietic cells modulates proliferation via MAP kinase--ERK-1/2 and does not require tyrosine docking sites in the EPO receptor

Experimental Cell Research
Jingchun ChenStephen T Sawyer

Abstract

Primary erythroid cells and erythroid cell lines may synthesize and secrete tumor necrosis factor-alpha (TNF-alpha) following stimulation with erythropoietin (EPO). The effect of triggering TNF-alpha synthesis and secretion was investigated in erythroleukemia and myeloid cell lines: HCD57, DA3-EPOR, and BAF3-EPOR. The EPO-induced, membrane-bound form of autocrine TNF-alpha seemed to enhance proliferation of HCD57 and DA3-EPOR cells; however, the concentration of secreted autocrine/paracrine TNF-alpha was never sufficient to have an effect. Autocrine TNF-alpha acts through TNFRII receptors to stimulate proliferation. Modulation of mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK-1/2) activity by the membrane-bound form of autocrine TNF-alpha apparently played a central role in the control of EPO-dependent proliferation of HCD57 and DA3-EPOR cells. Primary erythroid cells and DA3-EPOR cells were found to express similar, high levels of both TNFRI and TNFRII, showing that differential expression of TNF-alpha receptors does not explain why primary cells are inhibited and DA3-EPOR cells are stimulated by autocrine TNF-alpha. BAF3 cells expressing a mutant EPOR with no cytoplasmic tyrosine residues wer...Continue Reading

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Citations

Oct 19, 2011·Stem Cells International·Ganesan KeerthivasanJohn D Crispino
Jun 6, 2009·Journal of Cancer Research and Clinical Oncology·Cristiana Lo NigroMarco Merlano
Sep 12, 2015·Biotechnology Journal·Ji Sun ChoiBrendan A C Harley
Jun 27, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku KimBrian E Leonard
Jun 14, 2008·American Journal of Physiology. Cell Physiology·Chhanda Bose, Kodetthoor B Udupa
Jun 4, 2017·Glycoconjugate Journal·Dulce Papy-Garcia, Patricia Albanese
Aug 29, 2017·Psychiatry Investigation·Yong-Ku Kim, Kyoung-Sae Na
May 11, 2019·Stem Cells International·Kshitiz Raj Shrestha, So Young Yoo
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A GewirtzStephen T Sawyer
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Kai YouXuewen Xu

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