PMID: 8964746Mar 1, 1996Paper

Erythropoietin does not demonstrate circadian rhythm in healthy men

Journal of Applied Physiology
D Roberts, D J Smith

Abstract

The hormone erythropoietin (Epo) produced in the kidneys in response to hypoxia stimulates the production of red blood cells. We measured serum Epo levels in 26 healthy men over a 24-h period to determine whether Epo is secreted according to a circadian rhythm. Samples were collected every 2-4 h, and Epo was measured by using a radioimmunoassay (INCSTAR Epo-trac). To determine whether blood collection had any effect on Epo production, one-half of the subjects began the collection period in the morning and the other half in the evening. Exercise and the use of prostaglandin inhibitors were prohibited to eliminate fluctuations in Epo production in response to discrete stimuli. The daily Epo concentration for all subjects combined was 15.5 +/- 5.3 (SD) U/l. No significant circadian variation in serum Epo concentrations was observed in either group or when both groups were combined; however, a measure of individual variance was observed (mean deviation = 0.8 +/- 0.4 U/l).

Citations

Apr 22, 1999·Medicine and Science in Sports and Exercise·P F BodaryG S McMillan
Jul 15, 1999·Journal of Sports Sciences·D Roberts, D J Smith
Sep 25, 2018·Frontiers in Physiology·Fatima Z KiboubIngrid Eftedal
Dec 14, 2006·European Journal of Applied Physiology·Gustave Savourey, Pietro E di Prampero
May 27, 2009·Nature Reviews. Nephrology·Birgit C P KochPiet M ter Wee
Oct 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Miklos Z MolnarIstvan Mucsi
Aug 3, 2018·European Journal of Preventive Cardiology·David MonteroAndreas J Flammer
Jun 23, 2010·European Journal of Endocrinology·P L KristensenB Thorsteinsson
Aug 25, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·C VentréC Martin
Aug 2, 2021·Kidney International·Lina K SciesielskiChristof Dame

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