Erythropoietin gene expression: developmental-stage specificity, cell-type specificity, and hypoxia inducibility

The Tohoku Journal of Experimental Medicine
Norio Suzuki

Abstract

Erythrocytes play an essential role in the delivery of oxygen from the lung to every organ; a decrease in erythrocytes (anemia) causes hypoxic stress and tissue damage. To maintain oxygen homeostasis in adult mammals, when the kidney senses hypoxia, it secretes an erythroid growth factor, erythropoietin (Epo), which stimulates erythropoiesis in the bone marrow. Recently, studies using genetically modified mice have shown that the in vivo expression profile of the Epo gene changes dramatically during development. The first Epo-producing cells emerge in the neural crest and neuroepithelium of mid-stage embryos and support primitive erythropoiesis in the yolk sac. Subsequently, Epo from the hepatocytes stimulates erythropoiesis in the fetal liver of later stage embryos in a paracrine manner. In fact, erythroid lineage cells comprise the largest cell population in the fetal liver, and hepatocytes are distributed among the erythroid cell clusters. Adult erythropoiesis in the bone marrow requires Epo that is secreted by renal Epo-producing cells (REP cells). REP cells are widely distributed in the renal cortex and outer medulla. Hypoxia-inducible Epo production both in hepatocytes and REP cells is controlled at the gene transcription...Continue Reading

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Citations

Oct 11, 2015·Pflügers Archiv : European journal of physiology·Norio Suzuki, Masayuki Yamamoto
Jun 20, 2015·Frontiers in Physiology·Tomokazu SoumaMasayuki Yamamoto
May 26, 2016·Pflügers Archiv : European journal of physiology·Katharina GerlBirgül Kurt
Apr 23, 2016·Organic & Biomolecular Chemistry·Yun-Kun QiLei Liu
Sep 29, 2017·Science Translational Medicine·Hirofumi HitomiKenji Osafune
Nov 24, 2016·Pediatric Pulmonology·Hajime TakayasuKouji Masumoto
Nov 27, 2019·Cellular and Molecular Life Sciences : CMLS·Jussi-Pekka TolonenJohanna Myllyharju
Jun 28, 2019·Frontiers in Cell and Developmental Biology·Ikuo Hirano, Norio Suzuki
May 21, 2021·Open Medicine·Fei LiXiang-Mei Chen

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