Erythropoietin in pediatric cardiac surgery: clinical efficacy and effective dose

Chest
H ShimpoI Yada

Abstract

We assessed the clinical efficacy and determined the effective dose of erythropoietin (EPO) in 48 children scheduled for open heart surgery without blood transfusion. The children were divided into three groups: group 1 (n=21) was treated with 300 U/kg of EPO; group 2 (n=11) was treated with 150 U/kg of EPO; and group 3 (n=16) was not treated with EPO. EPO was administered on the day of hospital admission (6 to 7 days prior to surgery), on the following day, immediately after surgery, and on the following day. Immediately after surgery, the hemoglobin concentration in groups 1 and 2 was significantly higher than that in group 3. The reticulocyte count in groups 1 and 2 was significantly higher than that in group 3. Open heart surgery was completed without transfusion in all 21 patients in group 1 (100%), 10 of 11 in group 2 (90.9%), and 11 of 16 in group 3 (68.8%). EPO caused no adverse reactions. In conclusion, EPO was effective as an adjuvant therapy for open heart surgery without blood transfusion in children. Administration of a relatively high dose of EPO (300 U/kg) seems to be effective for pediatric patients.

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Citations

Jan 16, 2002·The Annals of Thoracic Surgery·E R Stephenson, J L Myers
Jan 22, 2013·Journal of Clinical Anesthesia·Pierre LafèreCostantino Balestra
Oct 19, 2011·Pediatric Transplantation·William T MahleKirk R Kanter
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Sep 1, 2015·Revista española de anestesiología y reanimación·G J Yanes Vidal
Oct 11, 2017·Anesthesia and Analgesia·Jill M CholetteNabil Hassan
Sep 3, 2003·Paediatric Anaesthesia·A Pérez-FerrerL J Goldman
Mar 27, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brian R JacobsRichard J Brilli

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