Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity

Molecular Cancer Therapeutics
Matthew E HardeeKimberly L Blackwell

Abstract

Evidence for erythropoietin signaling has been shown in several nonhematopoietic tissues, including many tumor types. Clinically, recombinant erythropoietin treatment of malignancy-related anemia has yet to be definitively associated with any modulation of chemotherapy or radiotherapy efficacy. Preclinically, recombinant erythropoietin has been shown to increase tumor oxygenation, but the direct effects of recombinant erythropoietin on tumor cells that express erythropoietin receptor are not yet fully characterized. This study examined the effects of exogenous recombinant erythropoietin on rodent mammary adenocarcinoma cells (R3230) in vitro and in vivo, and determined the effects of systemic recombinant erythropoietin on tumor growth delay in Taxol treatment. We showed that systemic recombinant erythropoietin treatment of rats bearing R3230 mammary carcinomas induced an increase in phospho-Akt levels within tumor cells. This was associated with a decrease in the frequency of apoptotic cells in tumors from recombinant erythropoietin-treated animals, but did not noticeably affect tumor growth rate. In vitro studies revealed that not only does recombinant erythropoietin induce Akt phosphorylation, but it also stimulates phosphory...Continue Reading

References

Dec 2, 1999·Experimental Cell Research·D M WojchowskiT J Pircher
Aug 1, 2000·Kidney International·C Westenfelder, R L Baranowski
Jul 16, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Murat O ArcasoyZishan A Haroon
Aug 7, 2003·The Lancet Oncology·Brian Leyland-Jones, UNKNOWN BEST Investigators and Study Group
Oct 18, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sandeep BatraPunam Malik
Oct 14, 2004·Oncogene·Frank PajonkMichael Henke
Dec 14, 2004·The Oncologist·Louis Harrison, Kimberly Blackwell
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Kenneth MaieseZhao Zhong Chong
Apr 7, 2005·Journal of the National Cancer Institute·Julia BohliusAndreas Engert

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Citations

Aug 1, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jaime Sanz Ortiz
Jun 26, 2012·Psychiatry and Clinical Neurosciences·Guillaume FondDelphine Capdevielle
Aug 11, 2011·PloS One·Thilo WelschNathalia A Giese
Jul 19, 2013·PloS One·Steve ElliottCarol Johnson
Aug 1, 2012·Biologics : Targets & Therapy·Steve Elliott, Angus M Sinclair
Jan 18, 2014·The Journal of Clinical Investigation·Bing ZhouWilliam Y Kim
Aug 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sheng GaoCheng Lu
Mar 15, 2011·Experimental Cell Research·Matthew McKinney, Murat O Arcasoy
Apr 9, 2008·Progress in Neurobiology·Kenneth MaieseYan Chen Shang
Mar 18, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kenneth Maiese
Apr 28, 2007·Stem Cells·C Anthony Blau
Mar 12, 2010·Journal of Clinical Pharmacology·Kenneth MaieseJinling Hou
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brandon K Hadland, Gregory D Longmore
Jun 14, 2008·American Journal of Physiology. Cell Physiology·Chhanda Bose, Kodetthoor B Udupa
Jul 4, 2008·The Oncologist·Ferdinando Mannello, Gaetana A M Tonti
Aug 19, 2007·International Journal of Experimental Pathology·Michael E Grant
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pierre SaintignyJean-Charles Soria
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Murat O Arcasoy
Aug 9, 2008·Molecular Cancer Therapeutics·Peter SolárArthur J Sytkowski
Jul 2, 2009·Molecular Cancer Research : MCR·Jee-Yeong JeongLaurie Feldman

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