Erythropoietin measurements in severely traumatized patients

Acta Anaesthesiologica Scandinavica
R VialetC Martin

Abstract

Despite numerous studies in critically ill patients, physiological adaptation to acute anaemia and the pattern of erythropoietin (EPO) secretion has not been well described in severely injured patients. The aim of this study was to describe EPO secretion and its relationship with haemoglobin (Hb) levels in severely injured patients. We performed an observational, prospective clinical study in our intensive care unit (ICU). For all patients with severe trauma (Injury Severity Score>15), EPO measurement was obtained on admission, during the first 3 days and then when Hb level was measured. Maximal EPO level (EPOmax) and minimal Hb level (Hbmin) during the ICU stay was determined for all patients. One hundred and seventy-one consecutives patients were included (440 EPO measurements). Seventy-nine patients (46.2%) showed an increased value (> or =25 UI/l) EPOmax value. Most EPOmax values were observed early after the trauma [within 4 days for 63 patients (82.8%)]. Plotting EPOmax to Hbmin values show that a threshold Hbmin value of 105 g/l best discriminated patients with and without an elevated EPO secretion. Less than 10% of the patients with Hbmin<105 g/l did not increase their EPO secretion. In severely traumatized patients a m...Continue Reading

References

Jul 1, 1988·JAMA : the Journal of the American Medical Association·T S Kickler, J L Spivak
Dec 1, 1982·British Journal of Haematology·M E MillerJ F Garcia
Aug 1, 1994·British Journal of Haematology·L T GoodnoughD Ciavarella
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·T KlausenN V Olsen
Feb 1, 1997·Intensive Care Medicine·P RogiersJ L Vincent
Aug 1, 1997·Intensive Care Medicine·J F NavarroD Fuchs
Jan 1, 1996·Annales Françaises D'anesthèsie Et De Rèanimation·H Bricard
Jan 16, 2004·Critical Care Medicine·Marion Scharte, Mitchell P Fink
Feb 28, 2004·The Journal of Pharmacology and Experimental Therapeutics·N H Al-HunitiP Veng-Pedersen
Nov 6, 2004·Biopharmaceutics & Drug Disposition·N H Al-HunitiP Veng-Pedersen
Nov 14, 2006·The Journal of Trauma·Yohan RobinsonAndreas Oberholzer

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Citations

Jun 21, 2012·Critical Care Clinics·Michael Piagnerelli, Jean-Louis Vincent
Apr 19, 2008·Acta Anaesthesiologica Scandinavica·Y Robinson
Mar 17, 2012·Transfusion·Nina E GlassBryan A Cotton
Aug 25, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·C VentréC Martin

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