Erythropoietin production in rats with post-ischemic acute renal failure

Kidney International
C C TanK U Eckardt

Abstract

To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery. Hematocrit was significantly decreased two hours, 24 hours and one week after renal artery occlusion. A significant reduction in serum haptoglobin at two hours and an increase in serum LDH at 24 hours indicated that hemolysis was the likely cause of the initial fall in hematocrit. However, despite the reduced hematocrit, serum Epo concentrations were not significantly different from controls, suggesting that the anemia is maintained because of lack of an appropriate Epo response. Right renal Epo mRNA levels were not significantly different in all groups, but Epo mRNA levels in post-ischemic kidneys were 50 to 67% lower than in contralateral kidneys. However, Epo mRNA in the post-ischemic kidney was increased sixfold by acute hemorrhage, a rise comparable to the ninefold increase observed in contralateral kidneys. In ARF rats exposed to 7.5% O2 for four hours, right kidney Epo mRNA increased 200-fold over normoxic levels, to a value similar to sham-operated hypoxic controls. Epo mRNA in the post-ischem...Continue Reading

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Citations

Mar 10, 2005·Journal of Clinical Laboratory Analysis·Seiki ArugaYasuhiko Tomino
Jan 22, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rajit K Basu, Derek S Wheeler
Feb 23, 1999·Kidney International·C WestenfelderR L Baranowski
Jan 14, 2004·Kidney International·Samuel N HeymanSeymour Rosen
Oct 12, 2012·Molecular Biology and Evolution·Brendan G HuntMichael A D Goodisman
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeanie ParkAnitha Vijayan
Nov 12, 2005·European Journal of Clinical Investigation·K-U Eckardt, A Kurtz
Nov 14, 2008·Current Opinion in Critical Care·Wanja M Bernhardt, Kai-Uwe Eckardt
Oct 4, 2012·American Journal of Botany·Margarita V RemizowaPaula J Rudall
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Makiko MatsumotoMasaomi Nangaku

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