Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance.

Genes & Cancer
Yiting CaoJeremy N Rich

Abstract

Recombinant erythropoietin (EPO) is a growth factor used in the treatment of chemotherapy-induced anemia, but recent studies suggest that EPO may accelerate cancer growth. Although several cancers express EPO receptors (EPORs), the mechanism by which EPOR promotes tumor growth remains poorly understood. Glioblastomas display a cellular hierarchy of self-renewal and tumor propagation restricted to glioma stem cells (GSCs). We find that GSCs express higher levels of EPOR than matched non-stem glioma cells. Prospective enrichment for EPOR on GSCs increased neurosphere formation, suggesting that EPOR can select for a subset of GSCs with increased self-renewal capacity. Targeting EPOR expression with lentiviral mediated short hairpin RNA (shRNA) reduced GSC growth, survival, and neurosphere formation capacity, defining a crucial role for EPOR in GSC maintenance. We further find that STAT3 is an important mediator of EPOR signals in GSCs. EPOR knockdown attenuated the basal activation of STAT3 present in GSCs, and a small molecule inhibitor of STAT3 reduced GSC growth and survival. EPOR signaling was critical for survival in vivo, as targeting EPOR expression decreased GSC tumorigenic potential. Elevated EPOR expression also associat...Continue Reading

Citations

Dec 14, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jessica Amlin-Van SchaickKarlyne M Reilly
Aug 11, 2011·PloS One·Thilo WelschNathalia A Giese
Nov 11, 2010·Future Oncology·Jason P SheehanDeric M Park
Sep 30, 2014·Expert Review of Neurotherapeutics·G Kenneth GrayEtty N Benveniste
Dec 15, 2010·Expert Opinion on Drug Delivery·Sermin GencMurat Digicaylioglu
Apr 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shusheng CheZhiyong Yan
Jul 14, 2011·Experimental Cell Research·Elodie A PérèsEdwige Petit
Mar 15, 2011·Experimental Cell Research·Matthew McKinney, Murat O Arcasoy
Oct 16, 2015·Cancer Cell·David L SchonbergJeremy N Rich
May 12, 2010·Biochemical Pharmacology·Lin ChengJeremy N Rich
Jul 9, 2013·Molecular Aspects of Medicine·David L SchonbergJeremy N Rich
Aug 11, 2015·Frontiers in Oncology·Tracy SeymourFoteini Kakulas
Oct 20, 2012·Biochimica Et Biophysica Acta·Alina FilatovaBoyan K Garvalov
Nov 27, 2014·Frontiers in Immunology·Nataša DebeljakArthur J Sytkowski
Jun 4, 2015·PloS One·Yayoi YoshimuraKenji Tanigaki
Feb 22, 2012·Cancer Cell·Yanxin PeiRobert J Wechsler-Reya
Apr 10, 2012·European Journal of Pharmacology·Dimitry A Chistiakov, Vladimir P Chekhonin
Apr 26, 2011·Toxicology and Applied Pharmacology·Kyung-Hwan HyunSu-Jae Lee
Aug 2, 2014·Neuro-oncology·Qian XieMichael E Berens
Feb 2, 2017·The Journal of Clinical Investigation·Satoru Osuka, Erwin G Van Meir
Feb 23, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AaproUNKNOWN ESMO Guidelines Committee
Mar 7, 2014·The Journal of Biological Chemistry·Guang YuanGang Li
Jan 8, 2020·International Journal of Biometeorology·Song Hie JungChang Seok Lee
Feb 10, 2018·Oncotarget·Konstantin MasliantsevLucie Karayan-Tapon
Feb 28, 2013·International Journal of Molecular Sciences·Wenjing JiangKunlin Jin
Feb 1, 2019·Breast Cancer Research : BCR·Kruttika BhatFrank Pajonk
Jun 4, 2020·Cancers·Carla Lucia EspositoVittorio de Franciscis
Sep 17, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying ZhengEtty N Benveniste
Sep 26, 2020·Molecular Cancer Research : MCR·Tiantian CuiArnab Chakravarti
Oct 30, 2019·World Neurosurgery·Fabio TorregrossaGiovanni Grasso
May 4, 2021·Saudi Journal of Biological Sciences·Hareth Y ShujaaEdinAl-Shwyeh Hussah Abdullah
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AaproUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

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