Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure.

Kidney International
Surjit K SraiPaul A Sharp

Abstract

Erythropoietin is produced by the kidney and stimulates erythropoiesis; however, in chronic renal disease its levels are reduced and patients develop anemia that is treatable with iron and recombinant hormone. The mechanism by which erythropoietin improves iron homeostasis is still unclear, but it may involve suppression of the iron regulatory peptide hepcidin and/or a direct effect on intestinal iron absorption. To investigate these possibilities, we used the well-established 5/6th nephrectomy rat model of chronic renal failure with or without human recombinant erythropoietin treatment. Monolayers of human intestinal Caco-2 cells were also treated with erythropoietin to measure any direct effects of this hormone on intestinal iron transport. Nephrectomy increased hepatic hepcidin expression and decreased intestinal iron absorption; these effects were restored to levels found in sham-operated rats on erythropoietin treatment of the rats with renal failure. In Caco-2 cells, the addition of erythropoietin significantly increased the expression of apical divalent metal transporter 1 (DMT1) and basolateral ferroportin and, consequently, iron transport across the monolayer. Taken together, our results show that erythropoietin not on...Continue Reading

References

Dec 1, 1993·Journal of the American Geriatrics Society·E JoostenW Pelemans
Mar 1, 1996·Current Opinion in Hematology·G L Wang, G L Semenza
Mar 18, 2000·Pflügers Archiv : European journal of physiology·M W SmithS K Srai
Feb 21, 2002·Biochimica Et Biophysica Acta·Mark Williams, Paul Sharp
Jul 2, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ivor Cavill
Jan 31, 2004·Blood·Abas H LaftahSurjit K S Srai
Jun 18, 2004·Kidney International·Richard A ZagerSherry Y Hanson
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mitchell D KnutsonMarianne Wessling-Resnick
Mar 11, 2005·The New England Journal of Medicine·Guenter Weiss, Lawrence T Goodnough
May 20, 2005·The Biochemical Journal·Naveen SharmaChris Tselepis
Mar 29, 2006·The Biochemical Journal·Abas H LaftahChris Tselepis
May 23, 2006·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Paul Sharp
Apr 26, 2007·Kidney International·J MarksUNKNOWN Epithelial Transport and Cell Biology Group
Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Natalia P MenaMarco T Núñez
May 23, 2008·Journal of the American Society of Nephrology : JASN·Ko-Lin KuoDer-Cherng Tarng
Aug 12, 2008·Blood·Tomas GanzMark Westerman

❮ Previous
Next ❯

Citations

Oct 27, 2012·European Heart Journal·Ewa A JankowskaPiotr Ponikowski
May 17, 2013·Blood·Maria MastrogiannakiCarole Peyssonnaux
Nov 19, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Lucile MercadalUNKNOWN NephroTest Study Group
May 21, 2013·Nutrients·Konstantinos MandilarasFanis Missirlis
Aug 28, 2012·Blood Cells, Molecules & Diseases·Deborah ChiabrandoEmanuela Tolosano
Nov 13, 2012·The Journal of Pediatrics·Mervi TaskinenOuti Mäkitie
Jan 13, 2015·BioMed Research International·J C FernandesA Santos-Silva
Dec 4, 2013·Molecular Pharmaceutics·Junkai YanQing Yang
Aug 11, 2011·Blood Purification·Mahmut Ilker YilmazMehmet Kanbay
Mar 12, 2019·Current Opinion in Hematology·Cyril Renassia, Carole Peyssonnaux
Feb 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·D Merrill DaneConnie C W Hsia
Nov 12, 2014·Metallomics : Integrated Biometal Science·Robert J Simpson, Andrew T McKie
Oct 17, 2019·Nutrients·Sajidah Begum, Gladys O Latunde-Dada
Jan 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anatoly V SkalnyAlexey A Tinkov
Mar 21, 2020·Haematologica·Rafiou AgoroDespina Sitara
Jan 21, 2020·Transplantation Proceedings·Juliana Miguel BilarMaria Lucia Ferraz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
C BokemeyerEuropean Organisation for Research and Treatment of Cancer (EORTC) Taskforce for the Elderly
© 2021 Meta ULC. All rights reserved