Erythropoietin responsiveness in polycythaemia vera.

British Journal of Haematology
D W Golde, M J Cline

Abstract

A liquid bone marrow culture technique was used to study erythropoiesis in polycythaemia vera. Three patients with the diagnosis of polycythaemia vera treated only by phlebotomy were compared to three healthy volunteers. Erythropoiesis in vitro was assessed by counts of nucleated red cells and 3H-thymidine incorporation into erythroid precursors. Human urinary erythropoietin was found to stimulate erythropoiesis in cultures from the polycythaemia patients as well as normals. The erythropoietin effect was blocked by a rabbit anti-erythropoietin antibody. These results suggest that some erythroid precursor cells maintain an intact erythropoietin response mechanism in polycythaemia vera. They also support clinical studies of this disorder indicating that some regulation by erythropoietin may occur in vivo.

References

Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J R StephensonM M Shreeve
Sep 1, 1974·British Journal of Haematology·D W GoldeM J Cline
Mar 29, 1968·Annals of the New York Academy of Sciences·J C SchooleyV W Havens
May 23, 1970·Lancet·A CampbellT A Prankerd
Feb 1, 1973·The Journal of Clinical Investigation·C H SrodesD R Boggs
May 1, 1973·The Journal of Pediatrics·J J GershanikR Duncan
Dec 1, 1971·British Journal of Haematology·A S Gordon

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Citations

Jan 1, 1976·American Journal of Hematology·D W Golde, M J Cline
May 12, 1977·The New England Journal of Medicine·B R Greenberg, D W Golde
May 1, 1977·The Journal of Clinical Investigation·E D ZanjaniL R Wasserman
Apr 1, 1978·The Journal of Clinical Investigation·J F PrchalP J Fialkow
Oct 20, 1999·Critical Reviews in Biotechnology·B K SinghK K Tripathi
Jan 1, 1994·Critical Reviews in Microbiology·P G DeoN G Karanth
Jan 1, 1978·CRC Critical Reviews in Clinical Laboratory Sciences·W J Popovic, J W Adamson

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