PMID: 10412779Jul 21, 1999Paper

Erythropoietin supplement increases plasma lipoprotein lipase and hepatic triglyceride lipase levels in hemodialysis patients

Kidney International. Supplement
T GotoS Yukawa

Abstract

We reported in previous studies that plasma triglyceride levels, as well as remnant-like particles-cholesterol (RLP-C) and -triglyceride (RLP-TG) levels, were significantly lower in maintenance hemodialysis (HD) patients treated with erythropoietin (EPO) than in HD patients treated without EPO. However, little is known about the mechanisms underlying the improvements in abnormal RLP metabolism in HD patients. This study investigates whether EPO supplement therapy in cases of uremic anemia increases the plasma lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) levels in HD patients. Twenty HD patients who had not previously received EPO were divided into two groups according to the stage of HD: 12 at the initial stage, defined as a mean HD duration of 0.35 +/- 0.68 months (range of 0 to 2.47 months), and 8 at the maintenance stage, defined as a mean HD duration of 114.1 +/- 91.9 months (range of 13.0 to 253.9 months). Fasting plasma was collected from the HD patients prior to the start of the EPO supplement therapy and at one month after the therapy. RLP-C levels were determined using a RLP-C JIMRO II kit. Fasting plasma was also collected from the HD patients 10 minutes after an intravenous injection of heparin (30...Continue Reading

References

Apr 15, 1995·Thrombosis Research·R KnöflerA Takada
Mar 1, 1994·Kidney International·C A PollockC R George
Jan 1, 1994·Journal of Atherosclerosis and Thrombosis·K NakajimaT Murase
May 1, 1997·Journal de pharmacie de Belgique

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Citations

Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vladimír TeplanUNKNOWN Czech multicenter study
Jul 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kostas C SiamopoulosAlexandros D Tselepis
Apr 14, 2000·Current Opinion in Pediatrics·S Hingorani, S L Watkins
Nov 25, 2004·The International Journal of Artificial Organs·V Stefanovic, M Milojkovic

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