PMID: 11328280May 1, 2001Paper

Erythropoietin synthesis by tumour tissues in a patient with uterine myoma and erythrocytosis

British Journal of Haematology
M SuzukiI Sato

Abstract

We report a patient with uterine myoma (leiomyoma) and erythrocytosis in whom erythropoietin (Epo) production in the leiomyoma tissue was identified by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). A 48-year-old Japanese woman with uterine myoma showed marked erythrocytosis (haemoglobin: 20.2 g/dl, haematocrit: 61.1%, red blood cells: 6.51 x 10(12)/1). After hysterectomy, erythrocytosis rapidly disappeared. In the leiomyoma tissue collected from the patient, Epo mRNA expression was confirmed using RT-PCR. Furthermore, ELISA showed that the Epo protein level was significantly increased compared with those in control tissues. It is suggested that the pathogenesis of erythrocytosis in patients with uterine myoma involves ectopic Epo production by leiomyoma tissues.

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Citations

Nov 3, 2011·Neurocritical Care·Jonathan Graff-RadfordKelly D Flemming
Jan 1, 2010·BMJ Case Reports·Jyothi PadavalaSimon Emery
Dec 17, 2009·Hematology·Mary Frances McMullin
Sep 10, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·F NaritaK Fukunaga
Jun 9, 2009·Experimental Hematology·Walter Fried
Feb 14, 2003·Mayo Clinic Proceedings·Ayalew Tefferi
Sep 24, 2005·Mayo Clinic Proceedings·Ayalew Tefferi, Tiziano Barbui
Oct 1, 2008·International Journal of Laboratory Hematology·M F McMullin
Jul 21, 2007·International Journal of Cancer. Journal International Du Cancer·Michael S WiesenerKai-Uwe Eckardt
Mar 29, 2011·International Journal of Cancer. Journal International Du Cancer·Tania V LopezLeticia Rocha-Zavaleta
Jun 20, 2006·Best Practice & Research. Clinical Haematology·Ayalew Tefferi
Oct 29, 2013·Obstetrics and Gynecology International·Andrea CiavattiniPasquapina Ciarmela
Mar 1, 2015·American Journal of Obstetrics and Gynecology·Ryoko AsanoEtsuko Miyagi
Feb 20, 2014·Case Reports in Obstetrics and Gynecology·Yosuke OnoTakashi Arai
Apr 6, 2013·Fertility and Sterility·Md Soriful IslamPasquapina Ciarmela
Jan 13, 2005·The Journal of Veterinary Medical Science·Akiko YamauchiNobuo Sasaki
May 1, 2020·International Journal of Clinical Pharmacy·Nadia H MohammedZahraa Albasry
Mar 25, 2019·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Justin MuiHarold Hunt

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