Erythropoietin/erythropoietin-receptor system as an angiogenic factor in chemically induced murine hepatic tumors

International Journal of Clinical Oncology
Kiyoshi NakamatsuYoshiko Yasuda

Abstract

To clarify the role of erythropoietin (Epo) in hepatic tumor angiogenesis, expression of Epo and its receptor (Epo-R) and content of Epo were investigated in murine chemically induced hepatic tumors. To induce hepatic tumors and cirrhosis, diaminobenzidine was administered to Wistar rats for 5 months. In total, 30 hepatic tumors of greater than 3 mm in diameter were induced in 12 rats. The 30 hepatic tumors were resected with the surrounding hepatic tissues. The Epo content was measured by a radioimmunoassay (RIA) method. The number of tumor vessels in a definite area was counted in 100 areas of each tumor. To demonstrate the expression of Epo-R in tumors or surrounding liver tissues, immunohistochemical staining for Epo-R was performed. The Epo content of tumors ranged from 6.1 to 97.8 mU/ml, with a median of 21.8 mU/ml, which was significantly higher than that of the cirrhotic tissues adjacent to the tumors. Epo was not detectable in the normal or cirrhotic liver tissues without tumors. A significant correlation between Epo content and vascular density was noted in the 30 hepatic tumors (correlation coefficient, 0.480; P = 0.01). Immunoreactive Epo-R was detectable in the endothelium of intervening vessels of all hepatic tumo...Continue Reading

Citations

Oct 26, 2011·World Journal of Gastroenterology : WJG·Lin WangJun Lv
Dec 6, 2011·The Journal of Surgical Research·Kathrin RupertusOtto Kollmar
Nov 27, 2014·Frontiers in Immunology·Nataša DebeljakArthur J Sytkowski
Jul 14, 2017·International Journal of Molecular Sciences·Patrícia KimákováNataša Debeljak
Dec 15, 2006·World Journal of Gastroenterology : WJG·Kodetthoor-B Udupa
Sep 30, 2018·Advanced Drug Delivery Reviews·Austin P VeithAaron B Baker

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