ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms

Cellular Immunology
Min SuLaijun Lai

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) derived from 129S6SvEv Tac mouse embryonic stem cells (mESCs) prevented the development of EAE. In this study, we expand our previous studies to show that transplantation of MOG expressing mESC-TEPs derived from C57BL/6 mice also prevents EAE development. Furthermore, by using a MOG-specific T cell receptor (TCR) transgenic mouse model, we demonstrate that both central and peripheral tolerances are involved in the prevention of EAE induced by MOG expressing mESC-TEPs. Our results suggest that transplantation of human ESC-TEPs expressing MOG may provide an effective approach for the induction of MOG-specific immune tolerance, thereby the prevention and treatment of MS.

Citations

Nov 20, 2018·Nature Reviews. Neurology·Adam E HandelGeorg A Holländer
Oct 30, 2018·Frontiers in Immunology·Sofia P das NevesFernanda Marques
Oct 28, 2020·Seminars in Immunopathology·Piero Alberti, Adam E Handel
May 28, 2019·Trends in Pharmacological Sciences·L A ValenteA J Filiano
Jul 2, 2021·Advanced Healthcare Materials·Catarina S SilvaNuno M Neves

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