Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis.

Proceedings of the American Thoracic Society
G J LaurentR C Chambers

Abstract

Lung fibrosis is a recognized feature of many chronic lung diseases and is central to the pathogenesis of idiopathic pulmonary fibrosis, a disease that carries a prognosis worse than many cancers. Current research into this condition is defining the key pathways of activation either in resident fibroblasts, matrix-producing cells derived from circulating fibrocytes, or epithelial cells that appear to transdifferentiate to fibroblast-like cells. The downstream signaling pathways are also being delineated as well as the gene interactions leading to altered cell phenotype. These studies have led to an appreciation that multiple pathways, including inflammatory and coagulation cascades, are involved in the pathogenesis of idiopathic pulmonary fibrosis. As these facts come to light, we are exploring promising new approaches to treat fibroses and halt the inexorable progression that is a feature of these disorders. This article reviews these findings and our current concepts of the key molecular events leading to tissue damage and excessive matrix deposition in lung fibrosis. It also highlights the need for new studies to delineate alternative pathogenetic mechanisms and integrate these pathways so we have a framework to better under...Continue Reading

References

Mar 1, 1992·The American Review of Respiratory Disease·A NagaiT Takizawa
Nov 1, 1992·American Journal of Respiratory Cell and Molecular Biology·A J PeacockG J Laurent
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·H MitsuhashiM Kiyoki
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·Y TaookaM Yamakido
Jul 2, 1998·The European Respiratory Journal·K DabbaghG J Laurent
Jul 10, 1998·The European Respiratory Journal·R K Coker, G J Laurent
Jul 7, 1999·The Journal of Clinical Investigation·K KuwanoN Hara
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·N KaminskiR A Heller
Mar 1, 2000·Gene Therapy·R G JenkinsS L Hart
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·R P MarshallG J Laurent
Feb 15, 2001·Annals of Internal Medicine·M SelmanUNKNOWN American College of Chest Physicians
Apr 18, 2001·International Archives of Allergy and Immunology·S T HolgateD E Davies
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Fengrong ZuoRenu A Heller
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Richard P MarshallGeoffrey J Laurent
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Anastasia PapafiliGeoffrey J Laurent
Apr 12, 2003·Critical Care Medicine·Theo J MoraesGregory P Downey
Apr 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Yuben P MoodleyDarryl A Knight
Jan 9, 2004·The New England Journal of Medicine·Ganesh RaghuUNKNOWN Idiopathic Pulmonary Fibrosis Study Group
Jan 15, 2004·The Journal of Clinical Investigation·Naozumi HashimotoSem H Phan
Jan 30, 2004·Annual Review of Medicine·Victor J ThannickalFernando J Martinez
Oct 29, 2004·The American Journal of Pathology·Rebecca J HodgesRobin J McAnulty
Nov 5, 2004·Developmental Cell·Masako TamadaYasuhiro Sawada
Feb 15, 2005·Experimental Cell Research·Olivier P Blanc-BrudeRachel C Chambers
Jul 7, 2005·Scandinavian Journal of Medicine & Science in Sports·A Sarasa-Renedo, M Chiquet
Feb 8, 2006·Annual Review of Physiology·Daniel J Tschumperlin, Jeffrey M Drazen
Mar 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Bethany B MooreGalen B Toews
May 25, 2006·Current Drug Targets·Jane E Howell, Robin J McAnulty
Jun 2, 2006·Proceedings of the American Thoracic Society·Victor J Thannickal, Jeffrey C Horowitz
Jun 27, 2006·Proceedings of the American Thoracic Society·Chun Geun LeeJack A Elias
Jul 15, 2006·American Journal of Respiratory and Critical Care Medicine·Michael R HillGeoffrey J Laurent
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kevin K KimHarold A Chapman
Dec 19, 2006·Biochemical and Biophysical Research Communications·Borna MehradRobert M Strieter
Jan 2, 2007·The International Journal of Biochemistry & Cell Biology·Robin J McAnulty
Jan 4, 2007·The American Journal of Pathology·Felix ChuaGeoffrey J Laurent

❮ Previous
Next ❯

Citations

Sep 15, 2010·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Aug 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Steven K HuangMarc Peters-Golden
Mar 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J A EldredI M Wormstone
Nov 12, 2010·Science Translational Medicine·Glenda TrujilloCory M Hogaboam
May 5, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Najmunnisa NasreenVeena B Antony
Feb 4, 2009·American Journal of Respiratory Cell and Molecular Biology·Priya KulasekaranJeffrey C Horowitz
Sep 1, 2009·American Journal of Respiratory Cell and Molecular Biology·Bryan RossAdel Giaid
Sep 25, 2012·American Journal of Respiratory Cell and Molecular Biology·Brian T GaribaldiLandon S King
Aug 24, 2010·Orphanet Journal of Rare Diseases·Annick ClementHarriet Corvol
Nov 19, 2008·Fibrogenesis & Tissue Repair·Kevin M Vannella, Bethany B Moore
Aug 27, 2010·Fibrogenesis & Tissue Repair·James C Bonner
Jan 12, 2013·American Journal of Respiratory and Critical Care Medicine·Rebecca L ToonkelMarilyn K Glassberg
Dec 10, 2015·Ocular Immunology and Inflammation·Tatjana S Sarenac VulovicNemanja S Zdravkovic
Feb 11, 2014·Clinics in Chest Medicine·Clare L Ross, Trevor T Hansel
Sep 13, 2012·Pulmonary Pharmacology & Therapeutics·David WrightAdrian R West
Apr 7, 2010·The American Journal of Medicine·Joyce S LeeTalmadge E King
Jan 29, 2013·Advances in Bioscience and Biotechnology·Thomas H SissonJeffrey C Horowitz
Sep 1, 2009·Lancet·Trevor T Hansel, Peter J Barnes
Dec 14, 2016·ERJ Open Research·Shengxing ZhengDavid R Thickett
Oct 31, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shengxing ZhengDavid R Thickett
Feb 11, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert V LumsdenMichael P Keane
Nov 7, 2019·Connective Tissue Research·Joanna BukowskaBarbara Gawronska-Kozak
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa MartinsClaudia F Benjamim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The Journal of Clinical Investigation
Harold A Chapman
The European Respiratory Journal
R K Coker, G J Laurent
© 2022 Meta ULC. All rights reserved