PMID: 6167655Aug 1, 1981Paper

Escape of metastasizing clonal tumor cell variants from tumor-specific cytolytic T lymphocytes

The Journal of Experimental Medicine
K Bosslet, V Schirrmacher

Abstract

A metastasizing variant of a chemically induced lymphoma from a DBA/2 mouse is shown to carry a distinct tumor-associated transplantation antigen (TATA), which can be recognized by syngeneic secondary anti-tumor cytolytic T lymphocytes (CTL). During metastasis of twice-cloned cell lines of this tumor, variants develop that are specifically immunoresistant to lysis by anti-tumor CTL. The variants are detected in the spleen of normal syngeneic mice. They remain stable over long-term passage in tissue culture. The high frequency with which these immunoresistant metastatic variants develop was found to explain the relative ineffectiveness of specific immunization against this metastatic tumor. Compared with organ-selective metastatic variants, the immunoresistant tumor variants seem to arise with a much higher frequency. The change in TATA expression described here differs from antibody-induced antigenic modulation in that it is more stable and genetically transmitted.

References

Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·E A BoyseL J Old
Sep 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·J W LITTLEFIELD

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Citations

Jan 1, 1982·Cancer Metastasis Reviews·V SchirrmacherL Beck
Jan 1, 1983·Cancer Metastasis Reviews·J E Talmadge
Jun 7, 2003·Advances in Enzyme Regulation·Ulf R RappRudolf Götz
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R D WortzelH Schreiber
Aug 1, 1993·Cell Biophysics·R M LafrenieF W Orr
Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·V SchirrmacherU Zangemeister-Wittke
May 1, 2013·Immunology and Cell Biology·Paul SpearCharles L Sentman
Jan 1, 1989·International Reviews of Immunology·A J George, F K Stevenson
Jan 1, 1986·Critical Reviews in Oncology/hematology·V P TerranovaR M Lyall
Nov 15, 1986·International Journal of Cancer. Journal International Du Cancer·P AltevogtV Schirrmacher
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·K Bosslet, V Schirrmacher
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·R SchwartzP F Mühlradt
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·R DzarlievaN F Fusenig
Mar 1, 1985·European Journal of Cancer & Clinical Oncology·M D KramerV Schirrmacher

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