ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma

Scientific Reports
Asna TungekarManoj Kashyap

Abstract

Esophageal cancer (EC) is the eighth most aggressive malignancy and its treatment remains a challenge due to the lack of biomarkers that can facilitate early detection. EC is identified in two major histological forms namely - Adenocarcinoma (EAC) and Squamous cell carcinoma (ESCC), each showing differences in the incidence among populations that are geographically separated. Hence the detection of potential drug target and biomarkers demands a population-centric understanding of the molecular and cellular mechanisms of EC. To provide an adequate impetus to the biomarker discovery for ESCC, which is the most prevalent esophageal cancer worldwide, here we have developed ESCC ATLAS, a manually curated database that integrates genetic, epigenetic, transcriptomic, and proteomic ESCC-related genes from the published literature. It consists of 3475 genes associated to molecular signatures such as, altered transcription (2600), altered translation (560), contain copy number variation/structural variations (233), SNPs (102), altered DNA methylation (82), Histone modifications (16) and miRNA based regulation (261). We provide a user-friendly web interface ( http://www.esccatlas.org , freely accessible for academic, non-profit users) tha...Continue Reading

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Citations

Dec 10, 2020·Biomarker Research·Sofia SaltaCarmen Jerónimo
Feb 12, 2021·Journal of Cellular and Molecular Medicine·Xiangming XuDuannuo Song

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Methods Mentioned

BETA
acetylation
ELISA
ATLAS

Software Mentioned

CRAN
PHP
MySQL
SimRel
Dragon
Cytoscape
GLOBOCAN
Ensembl
R
REVIGO

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