PMID: 7540828May 1, 1995Paper

Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins

Archives of Microbiology
S M Horne, K D Young

Abstract

A newly identified gene in Escherichia coli, fkpA, encodes a protein with extensive similarity to the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Chlamydia trachomatis. The FkpA protein may be a new member of the family of FK506-binding proteins (FKBPs) because its carboxyl domain includes a sequence that matches the consensus FK506-binding motif in 40 of 48 positions, including those amino acids at the active site that form hydrogen bonds with the drug FK506. The amino acid sequence of the 29 kDa FkpA protein is 30-35% identical to the Mip proteins of L. pneumophila, L. micdadei, and C. trachomatis. Of the 270 amino acids of FkpA, 113 (42%) are identical to the sequence of one or another of these Mip proteins. Overexpression of FkpA or deletion of fkpA from the E. coli chromosome had no detrimental effect on bacterial growth, indicating that fkpA is not an essential gene. Hybridization of fkpA-specific DNA probes to genomic blots revealed that similar genes exist in several representatives of the Enterobacteriaceae. Thus, mip-like genes are not found exclusively in bacteria having a predominately intracellular life style, but instead appear to be a new FKBP subfamily that is a common constit...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1992·Molecular Microbiology·A G LundemoseJ H Pearce
Dec 11, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C C TrandinhM H Saier
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N P Cianciotto, B S Fields
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J HeitmanM N Hall
Apr 1, 1991·Journal of Bacteriology·S KulakauskasD E Berg
Jul 1, 1990·The Journal of Infectious Diseases·N P CianciottoN C Engleberg
Sep 1, 1990·Infection and Immunity·N P CianciottoN C Engleberg
Apr 1, 1989·Infection and Immunity·N C EnglebergB I Eisenstein
Jan 1, 1987·Methods in Enzymology·J Vieira, J Messing
Mar 25, 1981·Journal of Molecular Biology·T F Smith, M S Waterman
Jan 1, 1993·Annual Review of Biophysics and Biomolecular Structure·F X Schmid
Jun 23, 1993·Annals of the New York Academy of Sciences·T Kino, T Goto
Jun 23, 1993·Annals of the New York Academy of Sciences·W H ParsonsM J Wyvratt
Jun 23, 1993·Annals of the New York Academy of Sciences·J Clardy
Sep 15, 1993·European Journal of Biochemistry·A Galat

❮ Previous
Next ❯

Citations

Mar 7, 1998·Molecular Microbiology·S TötemeyerI R Booth
Oct 6, 2010·BMC Microbiology·Yvonne MaternSusanne Behrens-Kneip
May 11, 2004·Microbial Cell Factories·Marika Miot, Jean-Michel Betton
Mar 1, 2015·Research in Microbiology·Athmanya Konegadde EshwarAngelika Lehner
Jul 25, 2006·Infection and Immunity·Sheryl S JusticeDavid A Hunstad
Mar 6, 2016·International Journal of Biological Macromolecules·Soumitra PolleySubrata Sau
Jun 28, 2005·Molecular Microbiology·Jesper E Mogensen, Daniel E Otzen
Nov 19, 2013·Biochimica Et Biophysica Acta·Camille GoemansJean-François Collet
Nov 2, 2005·The Journal of Biological Chemistry·Peter W M HermansSven Hammerschmidt
Jun 20, 1997·The Journal of Biological Chemistry·S HottenrottJ U Rahfeld
Jan 7, 1998·FEMS Microbiology Letters·C Pissavin, N Hugouvieux-Cotte-Pattat
Sep 7, 2001·Annual Review of Microbiology·T L Raivio, T J Silhavy
Jan 26, 2007·Molecular Plant-microbe Interactions : MPMI·Ning ZangJi-Liang Tang
Feb 3, 1999·Annual Review of Genetics·P N Danese, T J Silhavy
May 23, 2006·Nature Reviews. Microbiology·Gary RowleyMark Roberts
Mar 5, 2011·Annual Review of Biochemistry·Christine L HaganDaniel Kahne
Oct 29, 1998·Journal of Bacteriology·S W LazarR Kolter
Aug 28, 1999·Journal of Bacteriology·T L RaivioT J Silhavy
Aug 14, 2020·Journal of Medicinal Chemistry·Nicolas ScheupleinMitali Sarkar-Tyson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.