Escherichia coli K-12 clones that overproduce dam methylase are hypermutable.

Journal of Bacteriology
G Herman, P Modrich

Abstract

A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.

References

Mar 1, 1976·Bacteriological Reviews·B J BachmannA L Taylor
Apr 23, 1976·Molecular & General Genetics : MGG·G O HumphreysE S Anderson
Dec 1, 1976·Journal of Bacteriology·M G Marinus
Dec 1, 1976·Bacteriological Reviews·E M Witkin
Nov 11, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Wagner, M Meselson
Dec 14, 1973·Molecular & General Genetics : MGG·M G Marinus
May 15, 1974·Journal of Molecular Biology·M G Marinus, N R Morris
Sep 1, 1974·Journal of Bacteriology·E M Lederberg, S N Cohen
Feb 14, 1968·Journal of Molecular Biology·C Lark
Feb 14, 1968·Journal of Molecular Biology·D Billen
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B Glickman, M Radman
Dec 1, 1949·Journal of Genetics·D E LEA, C A COULSON

Citations

Jan 1, 1984·Molecular & General Genetics : MGG·R J CraigM G Marinus
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nina Costantino, Donald L Court
Nov 6, 2004·Microbiology·Piotr Zaleski, Andrzej Piekarowicz
Jan 23, 2016·Scientific Reports·Carlotta RondaAlex Toftgaard Nielsen
Jul 13, 2016·ELife·Yoshitaka KawasoeTatsuro S Takahashi
Sep 11, 2016·Applied and Environmental Microbiology·George PeabodyKaty C Kao
Aug 1, 2016·FEMS Microbiology Reviews·Satish Adhikari, Patrick D Curtis
Jul 1, 1992·Molecular Microbiology·A Løbner-OlesenM G Marinus
Jun 10, 1995·Molecular & General Genetics : MGG·A LyngstadaasE Boye
Apr 16, 1998·Molecular Microbiology·D J O'Sullivan, T R Klaenhammer
Jul 2, 2004·Molecular Microbiology·Michael E WatsonArnold L Smith
Jan 18, 2006·Nature Reviews. Microbiology·Steven E Finkel
Jan 1, 1982·Molecular & General Genetics : MGG·E Sledziewska-Gójska, C Janion
Jan 1, 1984·Journal of Molecular Evolution·M McClelland
Nov 14, 2001·Infection and Immunity·D A LowMichael J Mahan
May 24, 2001·Journal of Bacteriology·D C Bell, C G Cupples
Aug 18, 2016·MicrobiologyOpen·Qiuyan ShaoLanying Zeng
Feb 9, 2006·Chemical Reviews·Ravi R IyerP Modrich
Apr 19, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dragan Stajic, Lars E T Jansen
Aug 1, 1989·Journal of Bacteriology·V DamagnezM Radman
Mar 1, 1992·Journal of Bacteriology·E BoyeA Løbner-Olesen
Aug 1, 2009·EcoSal Plus·M G Marinus, A Løbner-Olesen
Jan 1, 1987·Molecular and Cellular Biology·P M GlazerW C Summers
Nov 1, 1988·Journal of Bacteriology·Z Miner, S Hattman
May 7, 1992·Biochimica Et Biophysica Acta·T H WuM G Marinus
Mar 1, 1988·Mutation Research·R S Lahue, P Modrich
Jul 1, 1983·Mutation Research·D M Podger

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.