Escherichia coli K-12 clones that overproduce dam methylase are hypermutable.

Journal of Bacteriology
G Herman, P Modrich


A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.


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