PMID: 6987663Feb 1, 1980Paper

Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction

Proceedings of the National Academy of Sciences of the United States of America
B W Glickman, M Radman

Abstract

Our approach to the isolation of DNA mismatch-correction-deficient mutants was based upon the isolation of 2-aminopurine-resistant second-site revertants of Escherichia coli dam- mutants. We isolated such second-site revertants which, when separated from the dam- mutation, have a mutator character of their own. These new mutators all mapped at three known mutator loci, mutH, mutL, and mutS, which exhibit the same mutagenic spectrum as the dam- mutator: increased levels of base substitution and frameshift mutations. The mutator potencies of double and triple mut- mutants suggest that these mutators are involved in the same general mismatch-repair pathway. All these mutations result in a hyper-recombination phenotype, but in four-factor crosses among lambda phages, a specific loss of intragenic recombination (Pam3 X Pam80) was found in mutL and mutS mutants, as would be predicted from the postulated role of mismatch correction in gene conversion and high negative interference phenomena.

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Citations

Mar 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Ninio
Oct 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L A Heywood, J F Burke
Jan 1, 1990·Journal of Basic Microbiology·D J SavicT Kostic
Jan 1, 1981·Zeitschrift für allgemeine Mikrobiologie·W Tröbner, R Piechocki
Jan 1, 1980·Molecular & General Genetics : MGG·H M Arthur, R G Lloyd
Nov 15, 1994·Molecular & General Genetics : MGG·E Grzesiuk, C Janion
Jan 1, 1987·Molecular & General Genetics : MGG·C DohetM Radman
Jan 1, 1982·Molecular & General Genetics : MGG·G Maenhaut-Michel, P Caillet-Fauquet
Jan 1, 1984·Molecular & General Genetics : MGG·J P ClaverysM Gherardi
Jan 1, 1983·Molecular & General Genetics : MGG·K Bebenek, C Janion
Oct 1, 1988·Molecular & General Genetics : MGG·E P EfimovaA A Belogurov
Jan 1, 1988·Molecular & General Genetics : MGG·A QuiñonesW Messer
Aug 1, 1988·Molecular & General Genetics : MGG·P Caillet-Fauquet, G Maenhaut-Michel
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Oct 1, 1993·Mutation Research·E Grzesiuk, C Janion

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