Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones

MSphere
Louise RoerHenrik Hasman

Abstract

Escherichia coli sequence type 410 (ST410) has been reported worldwide as an extraintestinal pathogen associated with resistance to fluoroquinolones, third-generation cephalosporins, and carbapenems. In the present study, we investigated national epidemiology of ST410 E. coli isolates from Danish patients. Furthermore, E. coli ST410 was investigated in a global context to provide further insight into the acquisition of the carbapenemase genes blaOXA-181 and blaNDM-5 of this successful lineage. From 127 whole-genome-sequenced isolates, we reconstructed an evolutionary framework of E. coli ST410 which portrays the antimicrobial-resistant clades B2/H24R, B3/H24Rx, and B4/H24RxC. The B2/H24R and B3/H24Rx clades emerged around 1987, concurrently with the C1/H30R and C2/H30Rx clades in E. coli ST131. B3/H24Rx appears to have evolved by the acquisition of the extended-spectrum β-lactamase (ESBL)-encoding gene blaCTX-M-15 and an IncFII plasmid, encoding IncFIA and IncFIB. Around 2003, the carbapenem-resistant clade B4/H24RxC emerged when ST410 acquired an IncX3 plasmid carrying a blaOXA-181 carbapenemase gene. Around 2014, the clade B4/H24RxC acquired a second carbapenemase gene, blaNDM-5, on a conserved IncFII plasmid. From an epidemi...Continue Reading

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Citations

Jun 19, 2019·Antimicrobial Agents and Chemotherapy·Christina A AhlstromJonas Bonnedahl
Aug 31, 2019·Annals of the New York Academy of Sciences·Katlego KopotsaNontombi Marylucy Mbelle
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Datasets Mentioned

BETA
AMA1167
YD786

Software Mentioned

BLASTN
Gubbins
MLST
BLAST
PhyML
BEAST
SPAdes assembler
GView
Burrows Aligner ( BWA )
GATK UnifiedGenotyper

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