ESCRT-III-mediated membrane repair in cell death and tumor resistance.

Cancer Gene Therapy
Jiao LiuDaolin Tang

Abstract

The plasma membrane is made of glycerophospholipids that separate the inner and outer parts of the cell. Under physiological conditions, it acts as a barrier and gatekeeper to protect cells from the environment. In pathological situations, it undergoes structural and functional changes, resulting in cell damage. Indeed, plasma membrane damage caused by various stresses (e.g., hypoxia, nutritional deficiencies, ultraviolet radiation, and chemotherapeutic agents) is one of the hallmarks of cell death. Phosphatidylserine exposure and plasma membrane blebbing usually occurs in apoptotic cells, while necrotic cells lose the integrity of the plasma membrane and thereby release intracellular damage-associated molecular patterns. In contrast, the endosomal sorting complex required for transport-III (ESCRT-III), an evolutionarily conserved protein complex with membrane fission machinery, plays a key role in the repair of damaged plasma membranes in various types of regulated cell death, such as necroptosis, pyroptosis, and ferroptosis. These emerging findings indicate that ESCRT-III is a potential target to overcome drug resistance during tumor therapy.

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Citations

Aug 18, 2020·Autophagy·Xin ChenDaolin Tang
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Feimei KuangRui Kang
Feb 5, 2021·Cell Chemical Biology·Feimei KuangRui Kang
Apr 13, 2021·Frontiers in Cell and Developmental Biology·Xin ChenDaolin Tang
May 21, 2021·Advanced Biology·Zhi LinDaolin Tang
Jun 4, 2021·Signal Transduction and Targeted Therapy·Ruoxi ZhangDaolin Tang
Jun 20, 2021·Biochemical and Biophysical Research Communications·Leng HanEnyong Dai
Jun 7, 2021·The FEBS Journal·Jiao LiuDaolin Tang
Jul 28, 2021·Trends in Molecular Medicine·Huanji XuFeng Bi
Sep 2, 2021·Cell Death and Differentiation·Xin ChenDaolin Tang

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Methods Mentioned

BETA
electron tomography

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