Esculetin ameliorates hepatic fibrosis in high fat diet induced non-alcoholic fatty liver disease by regulation of FoxO1 mediated pathway

Pharmacological Reports : PR
Anuradha PandeyAnil Bhanudas Gaikwad

Abstract

Non-alcoholic fatty liver disease (NAFLD), a chronic metabolic disorder is associated with oxidative stress, inflammation and fibrotic cascades. In this study, we aimed to examine the effects of Esculetin, a well-known anti-oxidant on TGF-β1 mediated liver fibrosis and FoxO1 activity. A non-genetic murine model for NAFLD was developed by chronic high fat diet (HFD) (58% calories from fats) feeding in Wistar rats. The plasma biochemical parameters, liver function tests, oxidative stress, and histopathological alterations were assessed. The alterations in extracellular matrix (ECM) deposition and FoxO1 activity were assessed by immunohistochemistry. The aberrations in plasma parameters, liver functioning, morphometric and microscopic changes in liver structure of HFD fed rats were significantly improved by treatment with Esculetin. Liver fibrosis, identified in the form of collagen deposition and expression of fibrotic proteins like TGF-β1 and fibronectin was also markedly controlled by Esculetin. The expression of phospho-FoxO1 was found to be reduced in HFD fed rats' liver, showing an increase in activation of FoxO1 under insulin resistant and hyperglycemic states. Esculetin treatment could improve phospho-FoxO1 expression, thu...Continue Reading

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Citations

Apr 1, 2019·Journal of Chromatographic Science·Yubo WangShijin Guo
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ming QiaoJunping Hu
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May 12, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Liubing LinYong Li
Nov 23, 2021·Phytotherapy Research : PTR·Linlin ZhangXiaofang Li

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