ESM-1 promotes adhesion between monocytes and endothelial cells under intermittent hypoxia

Journal of Cellular Physiology
Haili SunYongxiang Wei

Abstract

Intermittent hypoxia (IH), the key property of obstructive sleep apnea (OSA), is closely associated with endothelial dysfunction. Endothelial-cell-specific molecule-1 (ESM-1, Endocan) is a novel, reported molecule linked to endothelial dysfunction. The aim of this study is to evaluate the effect of IH on ESM-1 expression and the role of ESM-1 in endothelial dysfunction. We found that serum concentration of ESM-1, inter-cellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) is significantly higher in patients with OSA than healthy volunteers (p < 0.01). The expression of ESM-1, hypoxia-inducible factor-1 alpha (HIF-1α), and vascular endothelial growth factor (VEGF) was significantly increased in human umbilical vein endothelial cells (HUVECs) by treated IH in a time-dependent manner. HIF-1α short hairpin RNA and vascular endothelial growth factor receptor (VEGFR) inhibitor inhibited the expression of ESM-1 in HUVECs. ICAM-1 and VCAM-1 expressions were significantly enhanced under IH status, accompanied by increased monocyte-endothelial cell adhesion rate ( p < 0.001). Accordingly, ESM-1 silencing decreased the expression of ICAM-1 and VCAM-1 in HUVECs, whereas ESM-1 treatment significantly enhanced...Continue Reading

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Citations

Feb 23, 2020·Angiology·Ana Rita LeiteAdelino Leite-Moreira
Jul 10, 2019·Anti-cancer Agents in Medicinal Chemistry·Chen LiHua Xiong
Jul 28, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·João BessaTeresa Sousa
Jun 3, 2021·International Journal of Molecular Sciences·Jakub MocholAdrian Doroszko
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Anthony J Hayes, James Melrose
Jan 10, 2022·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mu-Di YaoBiao Yan

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