Esmolol and landiolol, selective beta1-adrenoreceptor antagonists, provide neuroprotection against spinal cord ischemia and reperfusion in rats

Anesthesia and Analgesia
Shino UmeharaYoko Masaki

Abstract

Paraplegia is a devastating and unpredictable complication occasionally resulting from surgery of the thoracic and thoracoabdominal aorta. Because ultrashort-acting selective beta(1)-adrenoreceptor antagonists provide neuroprotective effects after brain ischemia, we hypothesized that they would also ameliorate spinal cord injury after transient ischemia and reperfusion in rats. Male Sprague-Dawley rats were randomly assigned to one of the following 4 groups: saline (received IV infusion of 0.9% saline at a rate of 0.5 mL/h, n = 8), esmolol (esmolol 200 microg/kg/min, n = 8), landiolol (landiolol 50 microg/kg/min), or sham surgical (n = 6). Infusion of saline or drugs was initiated 30 minutes before spinal cord ischemia and continued for the subsequent 24-hour reperfusion. Spinal cord ischemia was induced by intraaortic balloon occlusion combined with proximal arterial hypotension for 10 minutes. The spinal cord was then reperfused for 24 hours. Ischemic injury was assessed in terms of the motor deficit index score of the hindlimb and the number of viable motor nerve cells in the anterior spinal cord at 24 hours after reperfusion. The motor deficit index scores were significantly lower in the esmolol and landiolol groups compare...Continue Reading

References

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Citations

Mar 13, 2015·Iranian Red Crescent Medical Journal·Murat SahinHuseyin Yildiz
Mar 27, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Jinyoung HwangSunghee Han
Jan 26, 2016·Neural Regeneration Research·Murat SahinHuseyin Yildiz
Mar 26, 2016·Journal of Cardiothoracic and Vascular Anesthesia·W Scott Jellish
Jun 29, 2013·European Journal of Pharmacology·Hayri KertmenZeki Sekerci

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