PMID: 11918517Mar 29, 2002Paper

Esomeprazole for acid peptic disorders

The Annals of Pharmacotherapy
Pramodini B Kale-PradhanWilliam T Sypula

Abstract

To review the pharmacology, pharmacokinetics, clinical efficacy, and safety of esomeprazole, a new proton-pump inhibitor (PPI). A MEDLINE search (1966-March 2001) was conducted for relevant literature using the terms esomeprazole, Nexium, and H199/18. Abstracts from the XXXII Nordic Meeting of Gastroenterology and journal articles provided by AstraZeneca were reviewed. All available studies on the pharmacology, pharmacokinetics, clinical efficacy, and safety of esomeprazole were reviewed. Esomeprazole is a new PPI and is the S-isomer of racemic omeprazole. Esomeprazole has demonstrated acid control comparable to that of the other PPIs currently available. Esomeprazole undergoes less hepatic metabolism compared with omeprazole, and thus may result in less interpatient variability among slow and fast metabolizers of CYP2C19. The oral bioavailability of esomeprazole is approximately 89% with a dose of 40 mg, and the half-life is approximately 1.5 hours. Esomeprazole is effective in the healing of erosive esophagitis, with a rate of healing at week 8 of 93.7% (p < 0.001). In maintenance therapy of healed erosive esophagitis, esomeprazole maintained healing rates >90% (6-mo trial). Esomeprazole is comparable with omeprazole (both in...Continue Reading

Citations

May 29, 2004·The American Journal of the Medical Sciences·Beth RosensheinHerbert Ho
Sep 17, 2011·Journal of Pharmaceutical and Biomedical Analysis·Santaji Uttam NalwadeNagendra Kumar Morisetti
Apr 27, 2007·ChemMedChem·Ian R BaxendaleGeoffrey K Tranmer
Mar 10, 2006·Journal of Pharmaceutical and Biomedical Analysis·Nov MarkovicClive A Prestidge
May 21, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·John W Devlin
Sep 29, 2012·Scandinavian Journal of Gastroenterology·Akihiro HigashidaHajime Yamada
Oct 3, 2002·Nature Reviews. Drug Discovery·Israel AgranatJohn Caldwell
May 30, 2003·The Annals of Pharmacotherapy·Brooke E SipeGordon H Bokhart
Apr 30, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C Scarpignato

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