Esomeprazole inhibits the pentagastrin-stimulated secretion of gastric acid in healthy Japanese volunteers

The Tohoku Journal of Experimental Medicine
Ryuhei MaejimaTooru Shimosegawa

Abstract

Gastroesophageal reflux disease (GERD) is a common disease, in which the reflux of gastric acid causes mucosal damage of the esophagus and/or troublesome symptoms. Esomeprazole, a proton pump inhibitor, has been used for treatment of GERD in Japan since 2011; namely, only little is known about its effect on gastric acid secretion in Japanese. We, therefore, assessed the relationship between dose and timing of esomeprazole administration and gastric acid inhibition in 11 healthy male Japanese volunteers by directly examining gastric acid secretion capacity. In this randomized, open-label, three-way crossover study, the subjects were dosed with esomeprazole 10 mg or 20 mg once a day (q.d.), or 20 mg twice a day (b.i.d.) for 14 days, and pentagastrin-stimulated gastric acid secretion was measured by endoscopic gastrin test. At steady states, gastric acid inhibition rates were significantly higher in esomeprazole 20 mg b.i.d. (median 100.0%, interquartile range [IQR] 99.4-100%, P = 0.027) or 20 mg q.d. (100.0%, IQR 99.7-100%, P = 0.016), compared with 10 mg q.d. (98.4%, IQR 84.4-100%). At trough states, esomeprazole 20 mg b.i.d. showed significantly higher gastric acid inhibition (99.6%, IQR 99.0-100%) than did 20 mg q.d. (84.2%, I...Continue Reading

References

Nov 1, 1989·Gut·B Joelsson, F Johnsson
Nov 20, 1998·The American Journal of Gastroenterology·K IijimaT Toyota
Sep 21, 2001·Alimentary Pharmacology & Therapeutics·T AnderssonM Hassan-Alin
May 15, 2004·Alimentary Pharmacology & Therapeutics·J Hammer, B Schmidt
Jul 16, 2008·Current Gastroenterology Reports·Ronnie Fass, Anita Gasiorowska
Aug 6, 2008·European Journal of Clinical Pharmacology·Shaojun Shi, Ulrich Klotz
Apr 15, 2009·Journal of Gastroenterology·Yasuhiro Fujiwara, Tetsuo Arakawa

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Citations

Dec 17, 2020·The Journal of International Medical Research·Youhong CaoZhenguo Qiao

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