Esophageal cancer in patients under 50: a SEER analysis

Journal of Thoracic Disease
Yuan ZengJianxing He

Abstract

Concomitant with rising rates of esophageal adenocarcinoma, there has been a significant increase of diagnoses among relatively younger individuals. However, most studies that focus on esophageal cancer (EC) in younger patients have had small sample sizes of patients treated at a single institute. The aim of this study was to analyze the clinical characteristics, outcomes and independent prognostic factors for EC in patients under 50-year-old using a large, multi-center dataset. The national Surveillance, Epidemiology, and End Results (SEER) database was analyzed for EC reported from 2004 to 2013. Patients were divided into two groups, those under 50-year-old and those 50 years or older, and comparisons were made regarding demographics, histology, stage distribution, treatment, overall survival (OS), and esophageal cancer-specific survival (ECSS). Multivariate Cox proportional hazard regression analyses were also used to identify independent prognostic factors. Among the 16,544 eligible patients, 1,385 (8.37%) were under 50 and 15,159 (91.63%) were over 50. Compared with the older group, patients under 50 were characterized by a higher frequency of males, lower esophagus involvement, adenocarcinoma histology, stage III/IV disea...Continue Reading

Citations

Feb 14, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Alexandra StraussGary W Falk
Oct 31, 2020·Expert Review of Gastroenterology & Hepatology·Min ShiZhi-Rong Cao
Dec 10, 2020·Cancer Reports·Abbas Ali Tasneem, Nasir Hassan Luck
May 29, 2021·The Surgical Clinics of North America·Jeremiah T Martin
May 28, 2019·The Journal of Thoracic and Cardiovascular Surgery·Tamar B NobelDaniela Molena
Jan 7, 2021·Journal of Clinical Gastroenterology·Prashanthi N ThotaMadhusudhan R Sanaka

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