PMID: 9527214Apr 4, 1998Paper

Esophageal carcinoma: depth of tumor invasion is predictive of regional lymph node status

The Annals of Thoracic Surgery
Thomas W RiceJohn R Goldblum

Abstract

The depth of tumor invasion (T) and regional lymph node status (N) are two factors that define the stage of an esophageal carcinoma. However, the arrangement of staging groups assumes that these factors are independent variables. A retrospective review of 359 consecutive patients undergoing esophageal resection was conducted to define the relationship between T and N and to determine whether T is a significant predictor of regional lymph node metastasis (N1). Primary treatment was operation without preoperative therapy. There were 295 (82%) adenocarcinomas, 55 (15%) squamous cell carcinomas, and 9 (3%) adenosquamous carcinomas. T status was Tis in 29 (8%) patients, T1 in 65 (18%), T2 in 37 (10%), T3 in 219 (61%), and T4 in 9 (3%). N status was N0 in 161 (45%) patients and N1 in 198 (55%). M status was M0 in 327 (91%) patients and M1 in 32 (9%). Stage was 0 in 29 (8%) patients, I in 58 (16%), IIA in 70 (20%), IIB in 22 (6%), III in 148 (41%), and IV in 32 (9%). The likelihood of N1 disease occurring with increasing T was tested using the trend test. The percentage of patients with N1 disease is 0% for Tis, 11% for T1, 43% for T2, 77% for T3, and 67% for T4 (p < 0.001). This relationship existed for both adenocarcinoma and squamo...Continue Reading

Associated Clinical Trials

Mar 24, 2015·Blair Jobe, MDBlair Jobe, MD

References

Oct 1, 1995·The Annals of Thoracic Surgery·J F SabikD J Adelstein
Jan 1, 1994·Surgical and Radiologic Anatomy : SRA·G MurakamiT Imazeki
Jan 1, 1993·Surgical and Radiologic Anatomy : SRA·M RiquetG Hidden

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Citations

May 24, 2006·Surgical and Radiologic Anatomy : SRA·Masaomi MizutaniWataru Kimura
Feb 2, 2012·Der Pathologe·G B Baretton, D E Aust
Mar 20, 2010·Digestive Diseases and Sciences·Kaushik MukherjeeWael El-Rifai
Mar 27, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Drew B Schembre
Sep 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Steven R DeMeester
Oct 15, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Bart P L WittemanBlair A Jobe
Aug 17, 2005·Current Problems in Cancer·Oleh HaluszkaBruce D Greenwald
Nov 26, 2008·Gastroenterology Clinics of North America·Attila DubeczJeffrey H Peters
Mar 12, 2004·The Journal of Surgical Research·Adam C Berger, Walter J Scott
Apr 20, 2001·The Annals of Thoracic Surgery·M J KrasnaUNKNOWN CALGB Thoracic Surgeons
Apr 10, 1999·The Annals of Thoracic Surgery·C E ReedR H Hawes
Jan 5, 2000·The Annals of Thoracic Surgery·T NishimakiT Iizuka
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Kenshi KugeShiro Sasaguri
Oct 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Steven R Demeester
Oct 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·T LerutUNKNOWN Leuven Collaborative Workgroup for Esophageal Carcinoma
Feb 24, 2001·Current Problems in Cancer·R Wong, R Malthaner
Dec 26, 2001·Surgical Oncology·M Pera, M Pera
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gregory G Ginsberg
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rodney J PacificoLori S Lutzke
Mar 17, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gregory Y LauwersMari Mino-Kenudson
Jun 3, 2009·Nature Reviews. Gastroenterology & Hepatology·Irving Waxman, Vani J A Konda
Sep 7, 2011·Nature Reviews. Gastroenterology & Hepatology·Aparna Repaka, Amitabh Chak
Mar 22, 2001·The British Journal of Surgery·J I GehR Glynne-Jones
Jun 9, 2009·Biostatistics·Hemant IshwaranThomas W Rice
Apr 12, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Brendon M StilesNasser K Altorki
Apr 25, 2014·Gastroenterology Report·Raja Shekhar Sappati Biyyani, Amithab Chak
Jun 23, 2001·Annals of Surgery·J M CollardP J Kestens
Oct 13, 2006·Current Opinion in Gastroenterology·S Law, J Wong
Dec 29, 2000·Journal of Clinical Gastroenterology·M TachibanaN Nagasue
Jun 10, 2004·Current Opinion in Oncology·Patrick Flamen
Apr 16, 2005·The American Journal of Surgical Pathology·Mari Mino-KenudsonGregory Y Lauwers
Jan 26, 2006·The American Journal of Surgical Pathology·Sjoerd M LagardeJ Jan B van Lanschot
Aug 8, 2008·The American Journal of Surgical Pathology·Hejin P HahnRobert D Odze
Jul 30, 2009·Annals of Surgery·Glyn G JamiesonSarah K Thompson
Dec 25, 2009·Annals of Surgery·Nabil P RizkEugene H Blackstone
Dec 27, 2005·Annals of Surgical Oncology·Steven R DeMeester

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