Esophageal epithelium of women with AIDS: thickness and local immunity

Pathology, Research and Practice
Laura RochaCamila Lourencini Cavellani

Abstract

The aim of this study was to evaluate the morphological characteristics of the esophageal epithelium (EE) and its local immunity. Esophageal fragments of autopsied women were collected from 1980 to 2008, and two groups were analyzed: with AIDS (n=17) and without AIDS (n=12). The measurement of the esophageal epithelium was carried out through the image analysis software ImageJ, and the immunostaining of Langerhans cells (LCs) was carried out using anti-S100 antibody. Women with AIDS, when compared with women without AIDS, had significantly thinner EE (220.6 versus 243.5 microm), a less number of LCs (6.2 versus 18.8 LCs/mm(2)), and a higher percentage of immature or morphologically altered LCs (66.6 versus 40.0%). The malnourished women, when compared with normonourished women, regardless of AIDS, had significantly thinner EE (227.1 versus 238.0 microm) and a less number of LCs (6.2 versus 12.5 LCs/mm(2)). The percentage of immature or morphologically altered LCs was the same in both groups. Additionally, the women with AIDS (7.0 versus 2.8%) and the malnourished women (5.8 versus 3.1%) presented a significantly higher percentage of fibrosis. We concluded that AIDS and malnutrition contribute to the decrease in esophagus local ...Continue Reading

References

May 7, 1999·Histopathology·M C Charton-BainF Potet
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Jul 17, 2007·Annals of Diagnostic Pathology·Janaína Valadares GuimarãesVicente de Paula Antunes Teixeira
Oct 1, 2008·BMC Genomics·Christina WagnerThomas Roeder

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Citations

Aug 17, 2012·Virchows Archiv : an International Journal of Pathology·Renata Beatriz SilvaCamila Lourencini Cavellani
Aug 28, 2012·Annals of Diagnostic Pathology·Humberto Aparecido FariaRosana Rosa Miranda Corrêa
Sep 22, 2016·Annals of Diagnostic Pathology·Grace Kelly Naves de Aquino FavaratoCamila Lourencini Cavellani
May 17, 2013·Journal of the International Association of Providers of AIDS Care·Camila Lourencini CavellaniLaura Penna Rocha
Sep 23, 2010·AIDS Research and Human Retroviruses·Laura Penna RochaCamila Lourencini Cavellani
Apr 8, 2017·Journal of Gastroenterology and Hepatology·Ana Luiza Werneck-SilvaMaria Irma Duarte

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