Esophageal functional impairments in experimental eosinophilic esophagitis.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Parm MaviAnil Mishra

Abstract

Eosinophilic esophagitis (EoE) is an emerging chronic esophageal disease. Despite the increasing diagnosis of EoE globally, the causes of EoE and other esophageal eosinophilic disorders are not clearly understood. EoE pathology includes accumulation of inflammatory cells (e.g., eosinophils, mast cells), characteristic endoscopic features (e.g., furrows, the formation of fine concentric mucosal rings, exudates), and functional impairments (e.g., esophageal stricture, dysmotility). We hypothesized that the esophageal structural pathology and functional impairments of EoE develop as a consequence of the effector functions of the accumulated inflammatory cells. We analyzed eosinophils (anti-major basic protein immunostaining), esophageal stricture (X-ray barium swallowing), and esophageal motility (isometric force) in two established transgenic murine models of EoE (CD2-IL-5 and rtTA-CC10-IL-13) and a novel eosinophil-deficient model (ΔdblGATA/CD2-IL-5). Herein, we show the following: 1) CD2-IL-5 and doxycycline (DOX)-induced rtTA-CC10-IL-13 mice have chronic eosinophilic and mast cell esophageal inflammation; 2) eosinophilic esophageal inflammation promotes esophageal stricture in both transgenic murine models; 3) the eosinophil-d...Continue Reading

References

Dec 1, 1989·Digestive Diseases and Sciences·A TøttrupR Dahl
Jan 1, 1986·Advances in Immunology·G J Gleich, C R Adolphson
Jun 1, 1983·The Journal of Experimental Medicine·M C O'DonnellL L Thomas
Jan 1, 1993·Digestive Diseases and Sciences·S E AttwoodJ B Jones
Jan 1, 1993·Annual Review of Medicine·G J GleichK M Leiferman
Nov 1, 1995·Digestive Diseases·T T Nostrant
Mar 1, 1996·International Archives of Allergy and Immunology·L B MartinG J Gleich
Aug 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·C J JustinichD L Kreutzer
Apr 29, 1998·Journal of Pediatric Gastroenterology and Nutrition·C A LiacourasE Ruchelli
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·A N MatthewsM E Rothenberg
May 29, 1998·The New England Journal of Medicine·M E Rothenberg
Jun 22, 1999·The Journal of Clinical Investigation·A MishraM E Rothenberg
Jan 3, 2001·The Journal of Clinical Investigation·A MishraM E Rothenberg
May 17, 2001·Current Gastroenterology Reports·S Vasilopoulos, R Shaker
Aug 25, 2001·The New England Journal of Medicine·T J Gross, G W Hunninghake
Dec 14, 2001·The Journal of Allergy and Clinical Immunology·M E RothenbergP E Putnam
Dec 14, 2001·The Journal of Allergy and Clinical Immunology·A StraumannH U Simon
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anil MishraMarc E Rothenberg
Jul 30, 2002·Gastrointestinal Endoscopy·Victor L FoxGlenn T Furuta
Oct 16, 2002·The International Journal of Biochemistry & Cell Biology·Annie Pardo, Moisés Selman
Dec 23, 2003·The American Journal of Gastroenterology·Chris A Liacouras, Jonathan E Markowitz
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Marc E Rothenberg
Feb 19, 2004·Drugs·Moisés SelmanJoseph P Lynch
Mar 5, 2004·Gastrointestinal Endoscopy·Jon W PotterWalter J Hogan
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard J NoelMarc E Rothenberg
Sep 16, 2004·Current Opinion in Pediatrics·Chris A Liacouras, Eduardo Ruchelli
Sep 18, 2004·Science·Alison A HumblesCraig Gerard
Sep 28, 2004·Journal of Pediatric Gastroenterology and Nutrition·A M G A Sant'AnnaE Drouin
Jun 29, 2005·Radiology·Stefan L ZimmermanDavid A Katzka
Dec 31, 2005·Journal of Pediatric Gastroenterology and Nutrition·Sandeep K GuptaHarm HogenEsch
Feb 3, 2006·The Journal of Clinical Investigation·Carine BlanchardMarc E Rothenberg
Jan 6, 2007·Journal of Pediatric Gastroenterology and Nutrition·Richard KirschErnest Cutz
Jan 18, 2007·The American Journal of Gastroenterology·Ana RuigómezStefan Eklund
Oct 9, 2007·Gastroenterology·Glenn T FurutaUNKNOWN First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees
Jan 15, 2009·Immunology and Allergy Clinics of North America·Anil Mishra
Jan 31, 2009·Journal of Pediatric Gastroenterology and Nutrition·Scott PentiukMarc E Rothenberg
Jun 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li ZuoMarc E Rothenberg
May 17, 2011·The Journal of Allergy and Clinical Immunology·Joseph D Sherrill, Marc E Rothenberg

❮ Previous
Next ❯

Citations

Jul 31, 2012·Seminars in Immunopathology·Seema AcevesMargaret H Collins
Sep 29, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Edaire ChengStuart J Spechler
Mar 28, 2013·PloS One·Thomas X LuMarc E Rothenberg
Nov 18, 2014·Clinical Practice·Asifa K ZaidiAnil Mishra
Dec 3, 2014·Immunology and Allergy Clinics of North America·Seema S Aceves
Dec 17, 2014·Current Problems in Pediatric and Adolescent Health Care·Neha Malhotra, Jeremiah Levine
Apr 30, 2013·Digestive Diseases and Sciences·Evan S Dellon
May 13, 2014·Gastroenterology Clinics of North America·Ikuo Hirano, Seema S Aceves
May 13, 2014·Gastroenterology Clinics of North America·Joshua B Wechsler, Paul J Bryce
Feb 3, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Á AriasM Vicario
Dec 1, 2015·Gastrointestinal Endoscopy Clinics of North America·Amanda B MuirChris A Liacouras
Nov 11, 2015·Best Practice & Research. Clinical Gastroenterology·Joel E Richter
Sep 2, 2014·The Journal of Allergy and Clinical Immunology·Hugh A SampsonRobert Wood
May 20, 2014·The Journal of Allergy and Clinical Immunology·Lisa Y BeppuSeema S Aceves
Jan 20, 2015·Current Treatment Options in Gastroenterology·Edaire Cheng
Sep 10, 2014·Pharmacology & Therapeutics·Hamish PhilpottSimon G Royce
Mar 2, 2016·Annual Review of Pathology·Benjamin P Davis, Marc E Rothenberg
Oct 28, 2016·Annals of the New York Academy of Sciences·Fouad J MoawadMirna Chehade
Feb 9, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Aakash Goyal, Edaire Cheng
Dec 14, 2017·Clinical Reviews in Allergy & Immunology·Mahsa EskianNima Rezaei
Jan 1, 2018·Clinical Reviews in Allergy & Immunology·Diana Muñoz-MendozaSami L Bahna
Jan 15, 2018·Clinical Reviews in Allergy & Immunology·Benjamin P Davis
Sep 14, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eisuke InageJoanne C Masterson
Jun 9, 2019·Clinical Reviews in Allergy & Immunology·Shelly Choudhury, Susan Baker
May 29, 2014·Current Opinion in Gastroenterology·Seema S Aceves
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Ángel Arias, Alfredo J Lucendo
May 1, 2020·Clinical and Translational Gastroenterology·Quan M NhuSeema S Aceves
Jan 17, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhenyu LiuShaoyong Yu
Jul 23, 2018·Clinical Reviews in Allergy & Immunology·Paul J DowlingBrooke I Polk
Aug 11, 2019·Journal of Translational Medicine·Elena CavalliSusanna Esposito
Apr 20, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rituraj NiranjanAnil Mishra
Oct 4, 2020·International Journal of Molecular Sciences·Seohyun RyuAndreas Kronbichler
Dec 7, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Melissa NelsonStuart Jon Spechler
Dec 24, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melissa NelsonRhonda F Souza
Sep 14, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Margaret H CollinsMarc E Rothenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Digestive Diseases and Sciences
Fouad J MoawadRoy K H Wong
American Journal of Physiology. Gastrointestinal and Liver Physiology
Rituraj NiranjanAnil Mishra
Proceedings of the National Academy of Sciences of the United States of America
Patricia C FulkersonMarc E Rothenberg
© 2022 Meta ULC. All rights reserved