Esophageal metastasis of stem cell-subtype hepatocholangiocarcinoma: Rare presentation of a rare tumor

World Journal of Gastroenterology : WJG
Maëva SalimonYann Touchefeu

Abstract

Hepatocholangiocarcinoma (cHCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable cHCC-ICC with stem-cell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis. Histological and immunohistochemical analyses of biopsies from the esophageal lesion and the hepatic tumor confirmed the diagnosis of cHCC-ICC with a stem cell-subtype, according to the World Health Organization classification. After a multidisciplinary meeting, the patient was treated with chemotherapy. He received two cycles of a gemcitabine plus cisplatin regimen before bone progression, and he died 3 mo after the initial diagnosis.

References

May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ArakawaK Okuda
Aug 1, 1996·Journal of Gastroenterology and Hepatology·J TaguchiM Kojiro
Jun 7, 2000·Gastrointestinal Endoscopy·N SoharaM Mori
Jun 9, 2005·Internal Medicine·Eiji TsubouchiIchinosuke Hyodo
Nov 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Li-Yi XieGuo-Liang Jiang
Oct 12, 2010·Endoscopy·T SatoR Soetikno
Jul 19, 2011·World Journal of Gastrointestinal Surgery·Wiroon BoonnuchArthur Andrew Christiano
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jan 1, 2014·European Journal of Radiology Open·Suresh MaximinNeeraj Lalwani
Aug 23, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·John R BergquistRory L Smoot

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