Esophageal peristaltic dysfunction in peptic esophagitis

Gastroenterology
P J KahrilasA Reece

Abstract

Esophageal exposure to acid is a major determinant in the pathogenesis of reflux esophagitis. In this study, we analyzed the esophageal peristaltic function of 177 patients and asymptomatic volunteers for abnormalities that could lead to prolonged esophageal acid clearance. The subjects were divided into five groups: normal volunteers, patient controls, patients with noninflammatory gastroesophageal reflux disease, patients with mild esophagitis, and ones with severe esophagitis. Manometric data were analyzed for the occurrence of failed primary peristalsis, for the occurrence of feeble peristalsis in the distal esophagus, and for hypotensive lower esophageal sphincter pressure. From an analysis of the data on control patients, peristaltic dysfunction was defined as the occurrence of either failed primary peristalsis or hypotensive peristalsis in the distal esophagus for over half of the test swallows. Peristaltic dysfunction was increasingly prevalent with increasing severity of peptic esophagitis, occurring in 25% of patients with mild esophagitis and 48% of patients with severe esophagitis. A correlation did not exist between the occurrence of peristaltic dysfunction and hypotensive lower esophageal sphincter pressure (less ...Continue Reading

Citations

Nov 1, 1992·Scandinavian Journal of Gastroenterology·P ParrillaV Garay
Apr 1, 1990·Digestive Diseases and Sciences·R O DantasL E Troncon
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·G Stacher, W Weiss
Feb 1, 1988·Digestive Diseases and Sciences·V F Eckardt
Jun 1, 1995·Alimentary Pharmacology & Therapeutics·G N TytgatM Verlinden
Jan 1, 1993·Dysphagia·J E Richter
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·J P Galmiche, J Janssens
Jan 1, 1996·Archives of Physiology and Biochemistry·I KaneJ P Barbier
Dec 16, 1998·Journal of the American Geriatrics Society·P O Katz
Mar 2, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K C KapurS A Riley
Apr 14, 1999·The American Journal of Gastroenterology·I LluchA Benages
Jan 15, 2000·Journal of Clinical Gastroenterology·D O Castell
Aug 15, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P GambittaR Arcidiacono
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·F MearinJ R Malagelada
Feb 24, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M BortolottiM Miglioli
Jul 20, 2001·Arquivos De Gastroenterologia·L F Silva, E M Lemme
Mar 20, 2003·The American Journal of Gastroenterology·Ronnie Fass
Jul 17, 2003·Pediatric Case Reviews·Chris A Liacouras
May 10, 2003·The American Journal of Gastroenterology·Peter J Kahrilas, John E Pandolfino
Jan 8, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·X ZhangD Sifrim
Jan 31, 2006·Arquivos De Gastroenterologia·Priscila Pollo FloresHenrique Sérgio Moraes Coelho
Sep 21, 2006·Alimentary Pharmacology & Therapeutics·H S KimH Park
Mar 1, 1991·Annals of Saudi Medicine·M I El-Mouzan
Sep 21, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T YigitB Oelschlager
Dec 14, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Kohsuke Uchida, Yuichiro Kamikawa
Apr 22, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S K GhoshJ G Brasseur
Jan 16, 2009·Journal of Gastroenterology and Hepatology·Takashi KawaiTatsuya Aoki
Nov 17, 2009·World Journal of Gastroenterology : WJG·Yasemin OzinBurhan Sahin
Nov 9, 2010·Journal of Pediatric Gastroenterology and Nutrition·Maria Rita Di PaceEnrico De Grazia
Jan 29, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C DaumM Fox
Nov 23, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M S RochaM G Patti
Jun 1, 2012·European Journal of Gastroenterology & Hepatology·Chien-Lin ChenTso-Tsai Liu
Aug 29, 2013·Journal of Gastroenterology and Hepatology·Chien-Lin ChenTso-Tsai Liu
May 2, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F B van HoeijA J Bredenoord
Jul 16, 2015·Scientific Reports·Shuo ZhangAlexander W Beham
Oct 29, 2015·Journal of Neurogastroenterology and Motility·Hironobu MikamiYoshikazu Kinoshita

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