Esophageal verrucous carcinoma arising from hyperkeratotic plaques associated with human papilloma virus type 51

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
J TonnaU Ladabaum

Abstract

Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. We report a case of esophageal verrucous carcinoma associated with human papilloma virus (HPV) type 51. The patient had long-standing dysphagia and odynophagia, and white esophageal plaques showing hyperkeratosis on biopsy. At repeat endoscopy, the esophagus was covered with verrucous white plaques and areas of nodular mucosa with white fronds, with a distal 10-cm smooth mass protruding into the lumen. Biopsies demonstrated an atypical squamoproliferative lesion but no frank malignancy. HPV type 51 DNA was detected in endoscopic biopsy specimens by polymerase chain reaction. Because the size of the lesion favored an underlying verrucous carcinoma, our patient underwent minimally invasive esophagectomy with gastric pull-up and cervical anastomosis. The pathologic diagnosis was a well-differentiated esophageal verrucous carcinoma. One year after esophagectomy, the patient feels well and is free of disease. Although HPV DNA was not detected in the cancer tissue obtained at surgery, our case suggests an association between HPV type 51 and esophageal verrucous carcinoma. The clinical evolution in this case highlights the importance of endoscopic ...Continue Reading

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Citations

Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Keyur ParikhDeepak Venkat
Jul 25, 2013·Histopathology·Melissa W TaggartSusan C Abraham
Oct 17, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S SweetserL M Wong Kee Song
Oct 28, 2016·Annals of the New York Academy of Sciences·Monika Tripathi, Paul E Swanson
Jul 18, 2014·World Journal of Clinical Cases·Chintan RamaniRamasamy Swami Nathan
Jun 1, 2018·Annals of the New York Academy of Sciences·Hala El-ZimaityRobert Riddell
Apr 10, 2020·Archives of Pathology & Laboratory Medicine·Deepika SavantZhaohai Yang
Aug 15, 2021·Journal of Digestive Diseases·Nian Di TanYing Lian Xiao

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