Esophageal Xanthoma: Presence of M2 Macrophages Suggests Association with Late Inflammatory and Reparative Processes

Open Medicine
Karina UeharaTakao Kinjo

Abstract

Esophageal xanthoma is a rare lesion which is an asymptomatic small yellowish polyp, and most of the reported cases were solitary lesion. Histologically, aggregations of foam cells are found under the papillary hypertrophic squamous epithelium and the foam cells express CD68. The etiology of esophageal xanthoma is unknown. The focal irritation of the esophageal mucosa and infiltrated inflammatory cells are presumed to contribute to its pathogenesis. Although the pathogenesis may be associated with inflammation, the type and nature of the macrophages remain unclear. Here we report a 46-year-old male with esophageal xanthoma, which was incidentally found by endoscopy. Histologically, acute inflammation was not noted, and immunohistochemistry revealed that the foam cells seen in this case of esophageal xanthoma expressed increased levels of M2 macrophage markers. These findings suggest that esophageal xanthoma is associated with late inflammatory and reparative processes long after the initial inflammation of esophageal squamous epithelium.

References

Nov 1, 1984·Endoscopy·W Remmele, B Engelsing
Aug 13, 2003·Journal of Gastroenterology and Hepatology·Mitsuyoshi HirokawaToshiaki Sano
Sep 25, 2003·Human Pathology·Roberto Herrera-GoepfertMartha García-Perales
Mar 6, 2007·Journal of Periodontology·Swati Y RawalDimitris N Tatakis
Jan 12, 2011·The Journal of Membrane Biology·Vladimir JurisicMija Colic
Jan 31, 2012·Gastroenterología y hepatología·Javier SalamancaPaloma Martín-Acosta
Jul 27, 2015·Cellular and Molecular Life Sciences : CMLS·Antonio SicaChiara Porta

❮ Previous
Next ❯

Citations

Dec 21, 2017·Gut·Kenta HamadaHiroyuki Okada
Sep 14, 2019·VideoGIE : an Official Video Journal of the American Society for Gastrointestinal Endoscopy·Robert BecharaPaul Manley
Nov 17, 2019·Trends in Immunology·Valentina Guerrini, Maria Laura Gennaro

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Virginia Medical Monthly
J B GORMAN, R N DE NIORD
Journal of Gastrointestinal and Liver Diseases : JGLD
Gabriel BecheanuJean-François Fléjou
Gastroenterología y hepatología
Javier SalamancaPaloma Martín-Acosta
The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
Lei ShiZhao-jiong Lu
© 2022 Meta ULC. All rights reserved