ESR and electrochemical study of 1,2-disubstituted 5-nitroindazolin-3-ones and 2-substituted 3-alkoxy-5-nitro-2H-indazoles: reactivity and free radical production capacity in the presence of biological systems

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Christian Folch-CanoChristian A Díaz-Urrutia

Abstract

Two families of 5-nitroindazole derivatives were electrochemically studied in an aprotic solvent using cyclic voltammetry (CV) technique. The produced nitro-anion radical species were characterized using electron spin resonance spectroscopy (ESR). Also, we examined the interaction between the radical species generated from nitroindazole derivatives and glutathione (GSH). Moreover, the capacity of intraparasite and intramammals-free radical production, through ESR spectroscopy, was performed.

References

Jan 2, 2003·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·C Olea-AzarWilliams Porcal
Feb 14, 2006·Mini Reviews in Medicinal Chemistry·C Olea-AzarR Briones
Apr 9, 2008·Biochimica Et Biophysica Acta·R Luise Krauth-Siegel, Marcelo A Comini

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Citations

Oct 23, 2013·Future Medicinal Chemistry·Benjamín Aguilera-VenegasHernán Speisky
Dec 12, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fernanda Pérez-CruzClaudio Olea-Azar
May 16, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Christian A Díaz-UrrutiaJuan D Maya
Mar 28, 2016·European Journal of Medicinal Chemistry·Cristina Fonseca-BerzalVicente J Arán
Jan 23, 2014·European Journal of Medicinal Chemistry·Beatriz MuroVicente J Arán

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