PMID: 15374470Nov 1, 1990Paper

ESR spin trapping studies on the OH* free radical reactions of idebenone

Archives of Gerontology and Geriatrics
I Zs -Nagy, R A Floyd

Abstract

Experiments have been performed using oxidized (ID-O) and reduced (ID-H) idebenone in various spin trapping systems. The following results were obtained. (1) ID-O does not have any detectable scavenger effect on the OH* free radicals when they are generated by means of Fenton reaction and trapped using DMPO, PBN or 4-POBN. (2) ID-H represents a serious competition for all spin traps used in capturing OH* free radicals. The mechanism of this competition is, however, not a direct reaction, but it is based on the rather quick autoxidation of the dissolved ID-H generating O2(-*) radicals. They interact with the OH* radicals (or with the OH-spin adducts) by means of electron donation to them. This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN). (3) The rate of autoxidation of ID-H in solution is about an order of magnitude faster than that of ubiquinone. Similar differences could be observed in the ra...Continue Reading

References

May 15, 1976·The Biochemical Journal·A BoverisA O Stoppani
Oct 15, 1978·FEBS Letters·C C WinterbournR F Claridge
May 1, 1989·Archives of Gerontology and Geriatrics·M SunoA Nagaoka
May 1, 1989·Archives of Gerontology and Geriatrics·M Suno, A Nagaoka
May 1, 1989·Archives of Gerontology and Geriatrics·M Suno, A Nagaoka
Aug 1, 1988·Journal of Cellular Physiology·M ShibanumaK Nose
Nov 1, 1980·The Biochemical Journal·J F Turrens, A Boveris
Jan 1, 1984·Methods in Enzymology·G M Rosen, E J Rauckman
Jan 1, 1984·Methods in Enzymology·G Czapski
Dec 28, 1984·Biochemical and Biophysical Research Communications·M Suno, A Nagaoka
Jan 1, 1984·Methods in Enzymology·M TakadaK Katayama
Jun 1, 1984·Japanese Journal of Pharmacology·M Suno, A Nagaoka
Nov 1, 1990·Archives of Gerontology and Geriatrics·I Zs -Nagy
Nov 1, 1990·Archives of Gerontology and Geriatrics·I SemseiI Zs -Nagy

❮ Previous
Next ❯

Citations

Nov 1, 1990·Archives of Gerontology and Geriatrics·I SemseiI Zs -Nagy
Nov 1, 1990·Archives of Gerontology and Geriatrics·K NagyI Zs -Nagy
Mar 1, 1991·Archives of Gerontology and Geriatrics·I Zs -Nagy
Nov 1, 1992·Archives of Gerontology and Geriatrics·M LingettiF Di Grazia
Nov 1, 1992·Archives of Gerontology and Geriatrics·G NappiM Fioravanti
Jan 1, 1997·Archives of Gerontology and Geriatrics·L BetaC Mariani
Dec 26, 1992·Annals of the New York Academy of Sciences·I Zs-Nagy
Dec 20, 2008·BioFactors·Isuke ImadaMasayasu Inoue

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.