ESR1-promoter-methylation status in primary breast cancer and its corresponding metastases.

Clinical & Experimental Metastasis
Verena KirnJochen Fries

Abstract

The role of ESR1 methylation in breast cancer and its influence on disease progression is not yet fully understood. Healthy breast tissue usually does not show ESR1 promoter methylation, whereas the frequency of ESR1 methylation appears to increase in primary breast cancer and in metastatic disease. Although women with ER positive breast cancer have a good prognosis, some will relapse. We aimed to evaluate the methylation status of ESR1 in primary breast cancer and its corresponding metastases by a methylation-specific real-time PCR and to correlate the methylation status with clinical outcome. Women who were treated for primary and metastatic breast cancer were included in the study. Tumor DNA was isolated from paraffin embedded tissue sections. After bisulfite treatment ESR1 promoter methylation was analyzed by real time-MSP of each tissue sample. Kaplan-Meier-Curves were drawn for survival. In the group of patients with positive ESR1 promoter methylation in the primary breast carcinoma survival was lower compared to the group of patients without methylation (38.1 months vs. 54.3 months, n.s.). Seven out of 19 (37%) of those patients with positive ESR1 promoter methylation developed loss of ER expression in metastatic disease...Continue Reading

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Citations

Feb 6, 2020·International Journal of Molecular Sciences·Sylwia PietrasikJanusz Blasiak
May 28, 2020·International Journal of Molecular Sciences·Elena S GardiniUlrike Ehlert
Mar 25, 2021·Journal of Cancer Research and Clinical Oncology·Jeffrey Chun Hin ChanWilliam C Cho

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Methods Mentioned

BETA
ESR
PCR
biopsy

Software Mentioned

SPSS

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