Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest

The Journal of Clinical Endocrinology and Metabolism
Douglas Paddon-JonesArny Ferrando

Abstract

We determined whether essential amino acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-(2)H(5)]phenylalanine. Net balance and FSR were calculated over 16 h, during which the control group (CON) received a nutritionally mixed meal every 5 h (0830, 1330, and 1830 h). The experimental group (EXP) also consumed 16.5 g essential amino acids and 30 g carbohydrate (1100, 1600, and 2100 h). The dietary regimen was maintained during bedrest. FSR was higher in the EXP group on d 1 (EXP, 0.099 +/- 0.008%/h; CON: 0.075 +/- 0.005%/h) and d 28 (EXP, 0.093 +/- 0.006%/h; CON, 0.055 +/- 0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP group (+0.2 +/- 0.3 kg), but fell in the CON group (-0.4 +/- 0.1 kg). Strength loss was more pronounced in the CON group (EXP, -8.8 +/- 1.4 kg; CON, -17.8 +/- 4.4 kg). Essential amino acid and carbohydrate supplementation may represent a viable intervent...Continue Reading

Citations

Jul 11, 2008·The Journal of Nutrition, Health & Aging·J E Morley
Jul 31, 2007·European Journal of Applied Physiology·A Pavy-Le TraonJ Vernikos
Mar 22, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E P DeutzRobert R Wolfe
Nov 5, 2011·The British Journal of Nutrition·Niikee SchoendorferPeter S W Davies
Aug 4, 2012·The British Journal of Nutrition·Charlotte G NeumannNimrod O Bwibo
Aug 13, 2013·Nutrition Research Reviews·Hugues MagneDominique Dardevet
Dec 6, 2007·Journal of Sports Sciences·Kevin D TiptonUNKNOWN International Association of Athletics Federations
Sep 6, 2011·Critical Reviews in Food Science and Nutrition·T Peter Stein, Stéphane Blanc
Oct 25, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Patrick KortebeinWilliam J Evans
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Alessandro LavianoFilippo Rossi-Fanelli
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Arny A FerrandoRobert R Wolfe
Feb 6, 2010·Critical Care Medicine·Melissa A ChambersMichael B Reid
Feb 6, 2010·Critical Care Medicine·Michael J Rennie
Dec 7, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Douglas Paddon-Jones, Heather Leidy
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Alan Hayes, Paul J Cribb
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Douglas Paddon-Jones, Blake B Rasmussen
Sep 11, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Martina Guadagni, Gianni Biolo
Nov 10, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Kirk L English, Douglas Paddon-Jones
Sep 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Elisa I Glover, Stuart M Phillips
Nov 16, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Yves RollandBruno Vellas
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Michael J Rennie
Nov 26, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jonathan P Little, Stuart M Phillips
Apr 13, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Elisa I GloverStuart M Phillips
Jun 19, 2010·American Journal of Respiratory and Critical Care Medicine·Eric B MilbrandtDerek C Angus
Nov 17, 2009·Medicine and Science in Sports and Exercise·Suzanne M SchneiderAlan R Hargens
Nov 8, 2006·Journal of Nutritional Science and Vitaminology·Gustavo Bajotto, Yoshiharu Shimomura
Sep 14, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mette Merete PedersenThomas Bandholm
Aug 17, 2011·Journal of Nutrition and Metabolism·Jennifer A BunnDarryn S Willoughby
Apr 5, 2013·Nutrition Reviews·Benjamin T Wall, Luc J C van Loon
Dec 25, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E Deutz, Robert R Wolfe
Dec 17, 2014·The Journal of Physiology·Stuart M Phillips, Chris McGlory
Aug 8, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rasmus BechshoeftLars Holm

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Arny FerrandoWilliam J Evans
The Journal of Clinical Endocrinology and Metabolism
Douglas Paddon-JonesArny Ferrando
© 2021 Meta ULC. All rights reserved