Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm

Development
Gianfranco BellipanniEric S Weinberg

Abstract

In Xenopus, Wnt signals and their transcriptional effector beta-catenin are required for the development of dorsal axial structures. In zebrafish, previous loss-of-function studies have not identified an essential role for beta-catenin in dorsal axis formation, but the maternal-effect mutation ichabod disrupts beta-catenin accumulation in dorsal nuclei and leads to a reduction of dorsoanterior derivatives. We have identified and characterized a second zebrafish beta-catenin gene, beta-catenin-2, located on a different linkage group from the previously studied beta-catenin-1, but situated close to the ichabod mutation on LG19. Although the ichabod mutation does not functionally alter the beta-catenin-2 reading frame, the level of maternal beta-catenin-2, but not beta-catenin-1, transcript is substantially lower in ichabod, compared with wild-type, embryos. Reduction of beta-catenin-2 function in wild-type embryos by injection of morpholino antisense oligonucleotides (MOs) specific for this gene (MO2) results in the same ventralized phenotypes as seen in ichabod embryos, and administration of MO2 to ichabod embryos increases the extent of ventralization. MOs directed against beta-catenin-1 (MO1), by contrast, had no ventralizing ...Continue Reading

References

Jan 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A InoueH Okamoto
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·B A RowningC A Larabell
Jan 27, 1998·Developmental Biology·V E Miller-BertoglioM E Halpern
Jan 1, 1997·Annual Review of Cell and Developmental Biology·R Harland, J Gerhart
Apr 16, 1998·Nature Genetics·J H PostlethwaitW S Talbot
Oct 24, 1998·Mechanisms of Development·F Pelegri, H M Maischein
Jun 22, 1999·Genomics·N ShimodaM C Fishman
Aug 17, 1999·Current Opinion in Genetics & Development·S Y Sokol
Feb 9, 2000·The Journal of Cell Biology·J HuelskenW Birchmeier
Apr 18, 2000·The Journal of Cell Biology·K I Takemaru, R T Moon
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A KawaharaI B Dawid
Nov 7, 2000·Genesis : the Journal of Genetics and Development·A KawaharaI B Dawid
Dec 16, 2000·Genome Research·I G WoodsW S Talbot
Mar 30, 2001·The Journal of Biological Chemistry·J PiedraA G de Herreros
Dec 19, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P Andermann, E S Weinberg
Mar 19, 2003·Development·Richard I DorskyAjay Chitnis
Jul 23, 2004·Development·Marie-Christine Ramel, Arne C Lekven
Oct 20, 2004·The Journal of Cell Biology·Cara J Gottardi, Barry M Gumbiner
Feb 15, 2005·Developmental Biology·Takashi ShimizuMasahiko Hibi
Aug 20, 2005·Genome Research·Ian G WoodsWilliam S Talbot
Nov 16, 2005·Annual Review of Genetics·Alexander F Schier, William S Talbot

❮ Previous
Next ❯

Citations

Feb 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlos CruzTetsuhiro Kudoh
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Fu-I LuBernard Thisse
Mar 1, 2012·The Journal of Biological Chemistry·Zhiqiang LiAnming Meng
Sep 6, 2011·Molecular Biology and Evolution·Riyue BaoMarkus Friedrich
Sep 25, 2012·Nucleic Acids Research·Yuan WangXinjing Tang
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Ewa StepniakValeri Vasioukhin
May 31, 2013·Development·Steven A HarveyJames C Smith
Oct 12, 2012·PLoS Biology·Shu-Yu WuLilianna Solnica-Krezel
Jan 1, 2012·Scientifica·Ellen Robertshaw, Clemens Kiecker
May 1, 2007·Regenerative Medicine·Lan Dang, Vincent Tropepe
Sep 29, 2011·Annual Review of Genetics·Yvette G Langdon, Mary C Mullins
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sarah E CheesmanKaren Guillemin
Sep 18, 2014·Journal of Proteome Research·Asfa Alli ShaikJayantha Gunaratne
Oct 23, 2014·Journal of Cellular Biochemistry·Fabio ValentiGianfranco Bellipanni
Aug 4, 2015·American Journal of Human Genetics·Lot Snijders BlokTjitske Kleefstra
Aug 7, 2010·Trends in Cell Biology·Rita TewariJuliet C Coates
Jul 18, 2009·Current Opinion in Genetics & Development·Elliott W Abrams, Mary C Mullins
Feb 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shunji Jia, Anming Meng
May 3, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Narudo KawaiHiroki Nishida
May 29, 2008·Developmental Neurobiology·Qin LiuDavid G Fatkins
Oct 25, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Shawn C Little, Mary C Mullins
Mar 12, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Isaac Skromne, Victoria E Prince
Apr 6, 2013·Journal of Cellular Physiology·Valentina MalafogliaGianfranco Bellipanni
Jul 1, 2015·Seminars in Cell & Developmental Biology·Francesca B Tuazon, Mary C Mullins
Jul 25, 2006·Current Opinion in Cell Biology·Wen-Hui LienValeri Vasioukhin
Aug 19, 2007·Developmental Biology·Engda G HagosScott T Dougan
Aug 11, 2007·Developmental Biology·Terence J Van RaayLilianna Solnica-Krezel
Feb 1, 2008·Gene·Valentina ChiniRosalba Gornati
Feb 20, 2007·Mechanisms of Development·Anne Grapin-Botton, Daniel Constam
Mar 13, 2008·Structure·Cara J Gottardi, Mark Peifer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.