PMID: 9001653Dec 1, 1996Paper

Essential fatty acid deficiency and predisposition to lung disease in cystic fibrosis

Acta Paediatrica
John D Lloyd-StillR T Holman

Abstract

Essential fatty acid (EFA) deficiency is a predisposing factor for pulmonary infection with Staphylococcus aureus and Pseudomonas aeruginosa, the two major pathogenic microorganisms in cystic fibrosis (CF). The goal of this study was to investigate the essential fatty acid status of CF patients from infancy to 20 years old. Plasma fatty acid profiles for phospholipid (PL) were determined for cord (n = 6), 4 months (n = 40), 16 months (n = 25), 3 y (n = 8), 5-10 y (n = 10), and 10-20 y (n = 10) aged CF patients and compared to their respective control; cord (n = 22), 1-36 months (n = 38) and adult (n = 100). Significance was established by Student's t-test (p < 0.05). The plasma PL fatty acid profile for all CF patients, except cord, revealed consistent deficiency in omega 3 and omega 6 EFAs. These deficiencies were most marked at infancy and more pronounced for patients with meconium ileus. EFA deficiency may contribute to the predisposition of CF infants to develop respiratory disease and to the excess cytotoxic activity found in bronchoalveolar lavage fluid at 2 months of age in the majority of screened infants.

References

Apr 2, 1977·Lancet·P SanjurjoJ Rodriguez-Soriano
Aug 21, 1992·Science·J N SnouwaertB H Koller
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T C HwangW B Guggino
Dec 1, 1991·The American Journal of Clinical Nutrition·J D Lloyd-StillR T Holman
Jan 1, 1991·The Journal of Pediatrics·K E HollidayK J Gaskin
Mar 1, 1990·The American Journal of Clinical Nutrition·S D PhinneyR T Holman
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·B StrandvikJ Carlstedt-Duke
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R T HolmanE Kokmen
Nov 1, 1989·The Journal of Pediatrics·J ReismanH Levison
May 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·S H AbmanC M Bowman
Dec 1, 1986·The American Journal of Clinical Nutrition·M C Craig-SchmidtC Y Wu
Dec 1, 1995·The American Journal of Clinical Nutrition·M T ClandininY K Goh
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·T Z KhanD W Riches
Jun 17, 1995·BMJ : British Medical Journal·D S ArmstrongP D Phelan
Jan 1, 1994·Lipids·R T HolmanJ W Crofts

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Citations

Nov 21, 2000·Pediatric Dermatology·G L DarmstadtV A Ziboh
Aug 23, 2006·The British Journal of Nutrition·Gabriel OlveiraFederico Soriguer
Aug 23, 2006·The British Journal of Nutrition·Birgitta Strandvik
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Drucy BorowitzVirginia Stallings
Apr 1, 1990·Acta paediatrica Scandinavica·J D Lloyd-StillH U Wessel
May 24, 2008·Annual Review of Nutrition·Sheila M Innis, A George F Davidson
Oct 24, 2009·Pediatric Research·Luis Aldámiz-EchevarríaJuan Rodríguez-Soriano
May 24, 2013·Nutrients·Lisa M HarrisonUma S Babu
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A LindbladB Strandvik
Aug 3, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Birgitta Strandvik
Feb 24, 2007·Clinical Biochemistry·Thierry Charles CosteTeresinha Leal
Apr 14, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Dominique TurckMichael Wilschanski
Feb 13, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Veronique GroleauVirginia A Stallings
Oct 30, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Peter WittersKris De Boeck
Apr 19, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Thierry NtimbaneBlandine Comte
Mar 2, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jacqueline A JumpsenM T Clandinin
Jan 18, 2003·Paediatric Respiratory Reviews·G Döring, D Worlitzsch
Jun 18, 2015·PloS One·Beatrice Alexandra Golomb, Alexis K Bui
Jan 21, 2017·International Journal of Molecular Sciences·Sławomira Drzymała-CzyżJarosław Walkowiak
Nov 30, 2006·Journal of Pediatric Gastroenterology and Nutrition·Carla ColomboCarlo Agostoni
Jan 14, 2012·Journal of Pediatric Gastroenterology and Nutrition·Marianne H JørgensenSusanne Lanng
Jun 16, 2012·Journal of Pediatric Gastroenterology and Nutrition·Asim MaqboolVirginia A Stallings
Oct 21, 2015·PloS One·Marlou P M AdriaanseAnita C E Vreugdenhil
Jan 6, 2016·The Cochrane Database of Systematic Reviews·Colleen Oliver, Helen Watson
Dec 10, 2015·The Cochrane Database of Systematic Reviews·Katharine ChengRosalind L Smyth
May 21, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasutada AkibaJonathan D Kaunitz
Apr 11, 2020·The Cochrane Database of Systematic Reviews·Helen Watson, Caroline Stackhouse
Mar 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sara MoukarzelSheila M Innis

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