Essential fatty acid treatment--effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats.

Diabetologia
D R TomlinsonP Keen

Abstract

This study was designed to examine the effect of dietary supplementation with essential fatty acids (evening primrose oil--5% weight:weight added to the diet) on acute neurophysiological and neurochemical defects in streptozotocin-diabetic rats. Diabetic rats, which were not given evening primrose oil, showed highly significant elevations of nerve sorbitol and fructose combined with a depletion of nerve myo-inositol. In those animals there was also a 40% reduction (p less than 0.02) in the accumulation of axonally transported substance P-like immunoreactivity proximal to a 12 h sciatic nerve ligature together with reduced motor nerve conduction velocity (13% [p less than 0.001] and 20% [p less than 0.001] in two separate experiments). Treatment of other diabetic rats with evening primrose oil prevented completely the development of the motor nerve conduction velocity deficit without affecting sorbitol, fructose or myo-inositol levels or the deficit in axonal transport of substance P. In a second experiment, treatment of diabetic rats with evening primrose oil was associated with significant attenuation of the conduction velocity deficit, but not complete prevention.

Citations

Apr 1, 1992·Diabetes/metabolism Reviews·D R Tomlinson
Oct 1, 1993·Diabetes/metabolism Reviews·D A GreeneS A Lattimer
Jul 1, 1992·Lipids·J ChattopadhyayH H Schmid
Mar 1, 1996·Journal of Lipid Mediators and Cell Signalling·P O Julu
Mar 1, 1996·Journal of Lipid Mediators and Cell Signalling·P O JuluG A Jamal
Aug 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·N E Cameron, M A Cotter
Jan 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·J EichbergR G Peterson
Jun 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F LauretaniL Ferrucci
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D F Horrobin
Jul 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M A Miller, R J Morgan
May 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·G A Jamal, H Carmichael
Aug 31, 2002·Diabetes/metabolism Research and Reviews·P J DickinsonA J M Boulton
Jan 5, 2000·The American Journal of Clinical Nutrition·R J HeadE J McMurchie
Mar 10, 2001·Diabetes/metabolism Research and Reviews·D BorenshteinZ Madar
Aug 27, 2018·Current Diabetes Reports·Mark A Yorek
Jan 1, 1992·Progress in Lipid Research·D F Horrobin
Apr 4, 2002·Journal of Agricultural and Food Chemistry·Geneive E HenryDavid L Dewitt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.